In:
BJU International, Wiley, Vol. 112, No. 7 ( 2013-11), p. 917-924
Abstract:
To analyse the predictive factors for worse pathological outcome (muscle invasive pT2 +, non‐organ‐confined pT3 + or N + and histological G rade 3) of upper tract urothelial carcinoma ( UTUC ) in a C hinese population from a nationwide high‐volume centre in C hina. Patients and Methods Predictors were studied by retrospectively reviewing the clinicopathological data of 729 consecutive patients with UTUC treated in our centre from J anuary 2002 to D ecember 2010. Univariate and multivariate logistic regression analyses were used. Results There were more female patients (56.4%) than males and more tumours were located in the ureter (52.7%) than in the pelvis. In multivariate analysis, male gender (hazard ratio [ HR ] 1.898, P = 0.001), sessile architecture ( HR 3.249, P 〈 0.001), high grade ( HR 5.007, P 〈 0.001), ipsilateral hydronephrosis ( HR 4.768, P 〈 0.001), renal pelvis location ( HR 2.620, P 〈 0.001) and tumour without multifocality ( HR 1.639, P = 0.028) were predictive factors for muscle‐invasive UTUC . Male gender ( HR 2.132, P 〈 0.001), renal pelvis location ( HR 3.466, P 〈 0.001), tumour without multifocality ( HR 2.532, P = 0.001), sessile tumour architecture ( HR 3.274, P 〈 0.001), and high grade ( HR 3.019, P 〈 0.001) were predictive factors for non‐organ‐confined disease. Chronological old age ( HR 1.047, P 〈 0.001), sessile tumour architecture ( HR 25.192, P 〈 0.001), ipsilateral hydronephrosis ( HR 1.689, P = 0.024), and positive urinary cytology ( HR 1.997, P = 0.006) were predictive factors for histological G rade 3 UTUC . Conclusions There was a predominance of female patients and ureteric tumours in UTUCs of this C hinese population. Male gender, sessile architecture, tumour location, tumour without multifocality, high histological grade and preoperative ipsilateral hydronephrosis were independent predictive factors for worse pathological outcome of UTUCs .
Type of Medium:
Online Resource
ISSN:
1464-4096
,
1464-410X
DOI:
10.1111/bju.2013.112.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2019983-1
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