In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 102, No. 3 ( 1983-03), p. 367-376
Abstract:
The thyroid function of 13 patients with proteinuria and normal serum creatinine level (Group 1) and 15 patients with proteinuria and increased creatinine level (Group 2) was investigated. The daily urinary T 4 1 -and T 3 excretion was much higher in Group 1 patients than in Group 2 patients (37.1 ± 25.9 nmol T 4 vs 17.5 ± 8.7 nmol T 4 , 3.3 ± 1.6 nmol T 3 vs 1.1 ± 0.8 nmol T 3 , respectively) and correlated in both groups with the protein loss. None of the patients suffered from hypothyroidism as a consequence of this hormone loss. Although the mean serum T 4 -, T 3 -, FT 4 -, FT 3 -, TBG-and TBPA concentrations in both groups of patients were within the normal range, the urinary hormone loss appeared to influence these values considerably. It was striking that the rT 3 concentration in the patients with the highest hormone loss was frequently less than 0.08 nmol/l, the lower limit of detectability. The basal TSH levels in serum of the nephrotic patients were similar to those of normal individuals. The thyroid function of patients with proteinuria accompanied by retention of creatinine due to renal failure was more difficult to assess because different pathological mechanisms may exert their influence on the thyroidal hormone secretion as well as on the peripheral hormone metabolism.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1020367
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1983
detail.hit.zdb_id:
1485160-X
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