In:
Infection and Immunity, American Society for Microbiology, Vol. 69, No. 4 ( 2001-04), p. 2364-2371
Abstract:
Uncertainty remains about the cellular origins of the earliest phase of the proinflammatory cytokine response to malaria. Here we show by fluorescence-activated cell sorter analysis that γδ T cells and CD14 + cells from nonimmune donors produce tumor necrosis factor and that γδ T cells also produce gamma interferon within 18 h of contact with mycoplasma-free Plasmodium falciparum -infected erythrocytes in vitro. This early cytokine response is more effectively induced by intact than by lysed parasitized erythrocytes. However, the IFN-γ response to lysed parasites is considerably enhanced several days after peripheral blood mononuclear cells are primed with low numbers of intact parasitized erythrocytes, and in this case it derives from both αβ and γδ T cells. These data show that naı̈ve γδ T cells can respond very rapidly to malaria infection but that malaria fever may involve a multistage process in which the priming of both γδ and αβ T-cell populations boosts the cytokine response to lysed parasite products released at schizont rupture.
Type of Medium:
Online Resource
ISSN:
0019-9567
,
1098-5522
DOI:
10.1128/IAI.69.4.2364-2371.2001
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2001
detail.hit.zdb_id:
1483247-1
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