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Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling

Ueno, Toshinori ; Nakashima, Ayumu ; Doi, Shigehiro ; [et al.]

Elsevier BV ; 2013

In: Kidney International Vol. 84, No. 2 ( 2013-08), p. 297-307

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In: Kidney International, Elsevier BV, Vol. 84, No. 2 ( 2013-08), p. 297-307

Type of Medium: Online Resource

ISSN: 0085-2538

URL: Article

DOI: 10.1038/ki.2013.81

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 2007940-0

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Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer

Shinagawa, Kei ; Kitadai, Yasuhiko ; Tanaka, Miwako ; [et al.]

Wiley ; 2013

In: International Journal of Cancer Vol. 132, No. 4 ( 2013-02-15), p. 813-823

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In: International Journal of Cancer, Wiley, Vol. 132, No. 4 ( 2013-02-15), p. 813-823

Type of Medium: Online Resource

ISSN: 0020-7136

URL: Article

DOI: 10.1002/ijc.27735

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2013

detail.hit.zdb_id: 218257-9

detail.hit.zdb_id: 1474822-8

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Dietary Phosphorus Acutely Impairs Endothelial Function

Shuto, Emi ; Taketani, Yutaka ; Tanaka, Rieko ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2009

In: Journal of the American Society of Nephrology Vol. 20, No. 7 ( 2009-07), p. 1504-1512

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In: Journal of the American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health), Vol. 20, No. 7 ( 2009-07), p. 1504-1512

Type of Medium: Online Resource

ISSN: 1046-6673

URL: Article

DOI: 10.1681/ASN.2008101106

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2009

detail.hit.zdb_id: 2029124-3

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Aging and vascular function

NOMA, Kensuke ; KIHARA, Yasuki ; HIGASHI, Yukihito

Japanese Society on Thrombosis and Hemostasis ; 2015

In: Japanese Journal of Thrombosis and Hemostasis Vol. 26, No. 3 ( 2015), p. 302-309

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In: Japanese Journal of Thrombosis and Hemostasis, Japanese Society on Thrombosis and Hemostasis, Vol. 26, No. 3 ( 2015), p. 302-309

Type of Medium: Online Resource

ISSN: 0915-7441 , 1880-8808

Uniform Title: 老化と血管機能

URL: Article

DOI: 10.2491/jjsth.26.302

Language: English , Japanese

Publisher: Japanese Society on Thrombosis and Hemostasis

Publication Date: 2015

detail.hit.zdb_id: 2395293-3

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Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model

Mikami, Shinsuke ; Nakashima, Ayumu ; Nakagawa, Keigo ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 7 ( 2013-7-4), p. e67739-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 7 ( 2013-7-4), p. e67739-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0067739

DOI: 10.1371/journal.pone.0067739.g001

DOI: 10.1371/journal.pone.0067739.g002

DOI: 10.1371/journal.pone.0067739.g003

DOI: 10.1371/journal.pone.0067739.g004

DOI: 10.1371/journal.pone.0067739.g005

DOI: 10.1371/journal.pone.0067739.g006

DOI: 10.1371/journal.pone.0067739.g007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

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Estimation of Arterial Viscosity Based on Oscillometric Method and Its Application to Vascular Endothelial Function Evaluation

Tanaka, Hiroshi ; Mito, Akihisa ; Matsumoto, Ryo ; [et al.]

Japan Society of Mechanical Engineers ; 2016

In: The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) Vol. 2016, No. 0 ( 2016), p. 1A2-02b6-

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In: The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec), Japan Society of Mechanical Engineers, Vol. 2016, No. 0 ( 2016), p. 1A2-02b6-

Type of Medium: Online Resource

ISSN: 2424-3124

Uniform Title: オシロメトリック法に基づく血管粘性推定法の提案と血管内皮機能評価への応用

URL: Article

DOI: 10.1299/jsmermd.2016.1A2-02b6

Language: English , Japanese

Publisher: Japan Society of Mechanical Engineers

Publication Date: 2016

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Edaravone (3-Methyl-1-Phenyl-2-Pyrazolin-5-one), A Novel Free Radical Scavenger, for Treatment of Cardiovascular Diseases

Higashi, Yukihito ; Jitsuiki, Daisuke ; Chayama, Kazuaki ; [et al.]

Bentham Science Publishers Ltd. ; 2006

In: Recent Patents on Cardiovascular Drug Discovery Vol. 1, No. 1 ( 2006-01-01), p. 85-93

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In: Recent Patents on Cardiovascular Drug Discovery, Bentham Science Publishers Ltd., Vol. 1, No. 1 ( 2006-01-01), p. 85-93

Type of Medium: Online Resource

ISSN: 1574-8901

URL: Article

DOI: 10.2174/157489006775244191

Language: English

Publisher: Bentham Science Publishers Ltd.

Publication Date: 2006

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Autologous Bone-Marrow Mononuclear Cell Implantation Reduces Long-Term Major Amputation Risk in Patients With Critical Limb Ischemia : A Comparison of Atherosclerotic Peripheral Arterial Disease and Buerger Disease

Idei, Naomi ; Soga, Junko ; Hata, Takaki ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2011

In: Circulation: Cardiovascular Interventions Vol. 4, No. 1 ( 2011-02), p. 15-25

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In: Circulation: Cardiovascular Interventions, Ovid Technologies (Wolters Kluwer Health), Vol. 4, No. 1 ( 2011-02), p. 15-25

Abstract: Bone-marrow mononuclear cell (BM-MNC) implantation improves ischemic symptoms in patients with critical limb ischemia (CLI). The purpose of this study was to evaluate long-term clinical outcomes after autologous BM-MNC implantation in patients with CLI. Methods and Results— We assessed long-term clinical outcomes after BM-MNC implantation in 51 patients with CLI, including 25 patients with peripheral arterial disease (PAD) and 26 patients with Buerger disease. Forty-six CLI patients who had no BM-MNC implantation served as control subjects. Median follow-up period was 4.8 years. The 4-year amputation-free rates after BM-MNC implantation were 48% in PAD patients and 95% in Buerger disease, and they were 0% in control PAD patients and 6% in control Buerger disease. The 4-year overall survival rates after BM-MNC implantation were 76% in PAD patients and 100% in Buerger disease, and they were 67% in control PAD patients and 100% in control Buerger disease. Multivariable Cox proportional hazards analysis revealed that BM-MNC implantation correlated with prevention of major amputation and that hemodialysis and diabetes mellitus correlated with major amputation. In Buerger disease, ankle brachial pressure index and transcutaneous oxygen pressure were significantly increased after 1 month and remained high during 3-year follow-up. However, in patients with PAD, ankle brachial pressure index and transcutaneous oxygen pressure significantly increased after 1 month and gradually decreased during 3-year follow-up and returned to baseline levels. Conclusions— These findings suggest that BM-MNC implantation is safe and effective in patients with CLI, especially in patients with Buerger disease. Clinical Trial Registration— URL: http://home.hiroshima-u.ac.jp/angio/ . Unique identifier: 001769.

Type of Medium: Online Resource

ISSN: 1941-7640 , 1941-7632

URL: Article

DOI: 10.1161/CIRCINTERVENTIONS.110.955724

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2011

detail.hit.zdb_id: 2450801-9

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Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells

Higashi, Yukihito ; Matsuoka, Hidehiro ; Umei, Hidekazu ; [et al.]

American Physiological Society ; 2010

In: American Journal of Physiology-Endocrinology and Metabolism Vol. 298, No. 2 ( 2010-02), p. E202-E209

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In: American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 298, No. 2 ( 2010-02), p. E202-E209

Abstract: Epidemiologic studies have shown that a low level of high-density lipoprotein (HDL) cholesterol is a risk factor for cardiovascular diseases. The purpose of this study was to determine the contribution of isolated low HDL cholesterol to endothelial function. Thirty-nine subjects with low HDL cholesterol who had no other cardiovascular risk factors were selected from the 5,417 participants from our population. We evaluated flow-mediated vasodilation (FMD) before and after 4 wk of treatment with the HMG-CoA reductase inhibitor pravastatin in 29 of the 39 subjects with isolated low HDL cholesterol. FMD was lower in the low-HDL-cholesterol group ( n = 29) than in the control group ( n = 29), whereas NTG-induced vasodilation was similar in the two groups. Pravastatin increased HDL cholesterol, urinary excretion of nitrite/nitrate, circulating levels of progenitor cells, and cell migration response to vascular endothelial growth factor in 15 subjects with low HDL cholesterol but not in 14 placebo control subjects. FMD increased in the pravastatin treatment group but not in the control group. NTG-induced vasodilation was similar before and after 4 wk of treatment in the two groups. Multiple regression analysis revealed that changes in HDL cholesterol, the number of progenitor cells, and migration of progenitor cells were independent predictors of augmentation of FMD with pravastatin. These findings suggest that low HDL cholesterol is an independent risk factor for endothelial dysfunction and that pravastatin improves endothelial function in individuals with isolated low HDL cholesterol through, at least in part, an increase in circulating progenitor cells.

Type of Medium: Online Resource

ISSN: 0193-1849 , 1522-1555

URL: Article

DOI: 10.1152/ajpendo.00394.2009

Language: English

Publisher: American Physiological Society

Publication Date: 2010

detail.hit.zdb_id: 1477331-4

SSG: 12

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The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial

Oyama, Jun-ichi ; Murohara, Toyoaki ; Kitakaze, Masafumi ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS Medicine Vol. 13, No. 6 ( 2016-6-28), p. e1002051-

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In: PLOS Medicine, Public Library of Science (PLoS), Vol. 13, No. 6 ( 2016-6-28), p. e1002051-

Type of Medium: Online Resource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/journal.pmed.1002051

DOI: 10.1371/journal.pmed.1002051.g001

DOI: 10.1371/journal.pmed.1002051.t001

DOI: 10.1371/journal.pmed.1002051.t002

DOI: 10.1371/journal.pmed.1002051.t003

DOI: 10.1371/journal.pmed.1002051.t004

DOI: 10.1371/journal.pmed.1002051.t005

DOI: 10.1371/journal.pmed.1002051.s001

DOI: 10.1371/journal.pmed.1002051.s002

DOI: 10.1371/journal.pmed.1002051.s003

DOI: 10.1371/journal.pmed.1002051.s004

DOI: 10.1371/journal.pmed.1002051.s005

DOI: 10.1371/journal.pmed.1002051.s006

DOI: 10.1371/journal.pmed.1002051.s007

DOI: 10.1371/journal.pmed.1002051.s008

DOI: 10.1371/journal.pmed.1002051.s009

DOI: 10.1371/journal.pmed.1002051.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2164823-2

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