In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 35, No. 4_suppl ( 2017-02-01), p. 101-101
Abstract:
101 Background: Preoperative malnutrition worsens morbidity and survival, however the role of post-gastrectomy nutritional status in survival remains unclear. The nutrition risk index (NRI) described by Buzby is a scoring system for identifying patients with preoperative poor nutrition status. However, the significance of NRI in evaluating post-gastrectomy nutritional status has not yet been established. Therefore, we aimed to clarify whether malnutrition condition evaluated by NRI after surgery can be a predictive factor for long-term survival in patients with gastric cancer. Methods: Pathological stage I, II, and III gastric cancer patients who underwent curative gastrectomy between 2002 and 2013 were included in this study. NRI was calculated using the following formula; (1.489 × serum albumin, g/L) + (41.7 × current weight/usual weight), and we defined an NRI of above 97.5 as normal nutrition (N group) and 97.5 or below as malnutrition (M group). NRI was evaluated before gastrectomy and 1, 3 and 12 months after gastrectomy. The correlations of clinicopathological characteristics, surgical treatment and overall survival, with nutritional status were retrospectively evaluated. Results: A total of 2552 patients were enrolled. There were significant differences in age, sex, body mass index, performance status, co-morbidity, histology and malignant stage between the groups before gastrectomy. Overall survival in the M group was significantly poorer, both before gastrectomy (adjusted HR 1.31; p 〈 0.001) and at 1 month (adjusted HR 1.52; p 〈 0.001), 3 months (adjusted HR 1.35; p = 0.004) and 12 months (adjusted HR 1.37; p = 0.006) after gastrectomy. In multivariate analysis, low NRI at 12 months after gastrectomy, age, co-morbidity and malignant stage were independently associated with overall survival. Overall survival in patients who fulfilled preoperative normal nutrition status criteria was also significantly poorer at 12 months after gastrectomy in the M group. Conclusions: Malnutrition after surgery, as well as before surgery, had a significant impact on overall survival. Postoperative nutritional statue evaluated by NRI may be a good predictive marker for long-term survival.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/JCO.2017.35.4_suppl.101
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2017
detail.hit.zdb_id:
2005181-5
Bookmarklink