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Lysophosphatidic acid depletes intracellular calcium stores different from those mediating capacitative calcium entry in C6 rat glioma cells

Hildebrandt, Jan-Peter ; Hildebrandt, Petra

Wiley ; 1997

In: Glia Vol. 19, No. 1 ( 1997-01), p. 67-73

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In: Glia, Wiley, Vol. 19, No. 1 ( 1997-01), p. 67-73

Type of Medium: Online Resource

ISSN: 0894-1491 , 1098-1136

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/(SICI)1098-1136(199701)19:1〈〉1.0.CO;2-D

DOI: 10.1002/(ISSN)1098-1136

DOI: 10.1002/(SICI)1098-1136(199701)19:1〈67::AID-GLIA7〉3.0.CO;2-7

Language: English

Publisher: Wiley

Publication Date: 1997

detail.hit.zdb_id: 1474828-9

SSG: 12

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Effects of Staphylococcus aureus-hemolysin A on calcium signalling in immortalized human airway epithelial cells

Eichstaedt, Stefanie ; Gäbler, Karoline ; Below, Sabine ; [et al.]

Elsevier BV ; 2009

In: Cell Calcium Vol. 45, No. 2 ( 2009-02), p. 165-176

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In: Cell Calcium, Elsevier BV, Vol. 45, No. 2 ( 2009-02), p. 165-176

Type of Medium: Online Resource

ISSN: 0143-4160

URL: Article

DOI: 10.1016/j.ceca.2008.09.001

Language: English

Publisher: Elsevier BV

Publication Date: 2009

detail.hit.zdb_id: 2002623-7

SSG: 12

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Attenuation of cell cycle regulator p27Kip1 expression in vertebrate epithelial cells mediated by extracellular signals in vivo and in vitro

Rohlfing, Anne-Katrin ; Schill, Tillmann ; Müller, Christian ; [et al.]

Springer Science and Business Media LLC ; 2005

In: Journal of Comparative Physiology B Vol. 175, No. 7 ( 2005-10), p. 511-522

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In: Journal of Comparative Physiology B, Springer Science and Business Media LLC, Vol. 175, No. 7 ( 2005-10), p. 511-522

Type of Medium: Online Resource

ISSN: 0174-1578 , 1432-136X

URL: Article

DOI: 10.1007/s00360-005-0019-x

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2005

detail.hit.zdb_id: 231245-1

detail.hit.zdb_id: 1459302-6

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S. aureus alpha-toxin monomer binding and heptamer formation in host cell membranes – Do they determine sensitivity of airway epithelial cells toward the toxin?

Möller, Nils ; Ziesemer, Sabine ; Hildebrandt, Petra ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS ONE Vol. 15, No. 5 ( 2020-5-29), p. e0233854-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 5 ( 2020-5-29), p. e0233854-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0233854

DOI: 10.1371/journal.pone.0233854.g001

DOI: 10.1371/journal.pone.0233854.g002

DOI: 10.1371/journal.pone.0233854.g003

DOI: 10.1371/journal.pone.0233854.g004

DOI: 10.1371/journal.pone.0233854.g005

DOI: 10.1371/journal.pone.0233854.s001

DOI: 10.1371/journal.pone.0233854.s002

DOI: 10.1371/journal.pone.0233854.s003

DOI: 10.1371/journal.pone.0233854.s004

DOI: 10.1371/journal.pone.0233854.s005

DOI: 10.1371/journal.pone.0233854.s006

DOI: 10.1371/journal.pone.0233854.r001

DOI: 10.1371/journal.pone.0233854.r002

DOI: 10.1371/journal.pone.0233854.r003

DOI: 10.1371/journal.pone.0233854.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2267670-3

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S. aureus haemolysin A-induced IL-8 and IL-6 release from human airway epithelial cells is mediated by activation of p38- and Erk-MAP kinases and additional, cell type-specific signalling mechanisms : Hla signalling and cytokine secretion by HAE cells

Räth, Susann ; Ziesemer, Sabine ; Witte, Amelie ; [et al.]

Hindawi Limited ; 2013

In: Cellular Microbiology Vol. 15, No. 7 ( 2013-07), p. 1253-1265

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In: Cellular Microbiology, Hindawi Limited, Vol. 15, No. 7 ( 2013-07), p. 1253-1265

Type of Medium: Online Resource

ISSN: 1462-5814

URL: Issue

URL: Article

DOI: 10.1111/cmi.2013.15.issue-7

DOI: 10.1111/cmi.12113

Language: English

Publisher: Hindawi Limited

Publication Date: 2013

detail.hit.zdb_id: 2019990-9

SSG: 12

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Expression levels and activities of energy-yielding ATPases in the oligohaline neritid snail Theodoxus fluviatilis under changing environmental salinities

Knobloch, Jan ; Müller, Christian ; Hildebrandt, Jan-Peter

The Company of Biologists ; 2022

In: Biology Open Vol. 11, No. 2 ( 2022-02-15)

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In: Biology Open, The Company of Biologists, Vol. 11, No. 2 ( 2022-02-15)

Abstract: The aquatic gastropod Theodoxus fluviatilis occurs in Europe and adjacent areas of Asia. The snail species has formed two genetically closely related subgroups, the freshwater ecotype (FW) and the brackish water ecotype (BW). Other than individuals of the FW ecotype, those of the BW ecotype survive in salinities of up to 28‰. Coastal aquatic ecosystems may be affected by climate change due to salinization. Thus, we investigated how the two Theodoxus ecotypes adjust to changes in environmental salinity, focusing on the question whether Na+/K+-ATPase or V-ATPase are regulated on the transcriptional, the translational or at the activity level under changing external salinities. Animals were gradually adjusted to extreme salinities in containers under long-day conditions and constant temperature. Whole body RNA- or protein extracts were prepared. Semi-quantitative PCR- and western blot-analyses did not reveal major changes in transcript or protein abundances for the two transporters under low or high salinity conditions. No significant changes in ATPase activities in whole body extracts of animals adjusted to high or low salinity conditions were detected. We conclude that constitutive expression of ATPases is sufficient to support osmotic and ion regulation in this species under changing salinities given the high level of tolerance with respect to changes in body fluid volume.

Type of Medium: Online Resource

ISSN: 2046-6390

URL: Article

DOI: 10.1242/bio.059190

Language: English

Publisher: The Company of Biologists

Publication Date: 2022

detail.hit.zdb_id: 2632264-X

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The Ins and Outs of Urea: Identification of Putative DUR3-like Urea Transporters in the Oligohaline Nerite Snail Theodoxus fluviatilis and Their Expression under Changing Salinities

Knobloch, Jan ; Gößeler, Sarah ; Fuchs, Laura I. R. ; [et al.]

MDPI AG ; 2023

In: Physiologia Vol. 3, No. 2 ( 2023-04-28), p. 281-294

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In: Physiologia, MDPI AG, Vol. 3, No. 2 ( 2023-04-28), p. 281-294

Abstract: Theodoxus fluviatilis (Linnaeus, 1758) (Gastropoda: Neritidae) is an oligohaline aquatic gastropod that inhabits most of Europe and adjacent areas of Asia. Two different ecotypes can be distinguished: One in freshwater (FW) and another along the Baltic Sea coast in brackish water habitats (BW). Individuals of either ecotype use free amino acids and urea as organic osmolytes to adjust body fluid osmolality to the external medium; however, the BW ecotype is able to accumulate them in larger quantities. The use of urea as an organic osmolyte in aquatic gastropods such as T. fluviatilis has only recently been initially described and raised the question of how urea transport between body fluids and the environment is balanced. Upon examining transcriptome and preliminary genome sequence data of T. fluviatilis, we identified putative homologues of DUR3 genes, which code for urea transporters (UTs) in other organisms. In this study, we provide evidence for the presence of four different subtypes of DUR3-like UTs that belong to two distinct families. Two of the UT subtypes were subject to qRT-PCR analyses to investigate differences in mRNA expression during the acclimation of individuals of both ecotypes to different salinities. Our results indicate that only BW animals regulate DUR3 gene expression in the context of osmoregulation.

Type of Medium: Online Resource

ISSN: 2673-9488

URL: Article

DOI: 10.3390/physiologia3020020

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 3136487-1

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Data_Sheet_1.pdf

Kivistik, Carmen ; Knobloch, Jan ; Käiro, Kairi ; [et al.]

Frontiers Media SA ; 2020

In: Frontiers in Microbiology Vol. 11 ( 2020-5-8)

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In: Frontiers in Microbiology, Frontiers Media SA, Vol. 11 ( 2020-5-8)

Type of Medium: Online Resource

ISSN: 1664-302X

URL: Article

DOI: 10.3389/fmicb.2020.00683

DOI: 10.3389/fmicb.2020.00683.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2020

detail.hit.zdb_id: 2587354-4

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Granulomatous inflammation of salt glands in ducklings ( Anas platyrhynchos ) associated with intralesional Gram-negative bacteria

Klopfleisch, Robert ; Müller, Christian ; Polster, Ulf ; [et al.]

Informa UK Limited ; 2005

In: Avian Pathology Vol. 34, No. 3 ( 2005-06), p. 233-237

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In: Avian Pathology, Informa UK Limited, Vol. 34, No. 3 ( 2005-06), p. 233-237

Type of Medium: Online Resource

ISSN: 0307-9457 , 1465-3338

URL: Article

DOI: 10.1080/03079450500112492

Language: English

Publisher: Informa UK Limited

Publication Date: 2005

detail.hit.zdb_id: 1476380-1

SSG: 22

SSG: 12,22

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Hirudin or hirudin‐like factor ‐ that is the question: insights from the analyses of natural and synthetic HLF variants

Müller, Christian ; Lukas, Phil ; Böhmert, Michel ; [et al.]

Wiley ; 2020

In: FEBS Letters Vol. 594, No. 5 ( 2020-03), p. 841-850

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In: FEBS Letters, Wiley, Vol. 594, No. 5 ( 2020-03), p. 841-850

Abstract: The hirudin‐like factor 1 (HLF1) of Hirudo medicinalis belongs to a new class of leech‐derived factors. In previous investigations, HLF1 did not exhibit anticoagulatory activities. Here, we describe the analysis of natural and synthetic variants of HLF1 and HLF‐Hyb, a yet uncharacterized member of the HLF family. Modifications within the N terminus of HLF1 have a strong impact on its activity. Some variants of HLF1 exhibit thrombin‐inhibiting activity comparable to hirudins, whereas others have reduced or no activity. The analyses of HLF‐Hyb variants revealed a strong impact of the central globular domain on activity. Our results indicate a comparable mode of action of hirudins and thrombin‐inhibiting HLF variants. Finally, we propose and discuss criteria for classifying hirudins and HLFs.

Type of Medium: Online Resource

ISSN: 0014-5793 , 1873-3468

URL: Issue

URL: Article

DOI: 10.1002/feb2.v594.5

DOI: 10.1002/1873-3468.13683

RVK:

WA 15000

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 1460391-3

SSG: 12

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