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  • 1
    Online Resource
    Online Resource
    Chitosan : A promising safe and immune-enhancing adjuvant for intranasal vaccines
    Informa UK Limited ; 2014
    In:  Human Vaccines & Immunotherapeutics Vol. 10, No. 3 ( 2014-03), p. 797-807
    Details
    In: Human Vaccines & Immunotherapeutics, Informa UK Limited, Vol. 10, No. 3 ( 2014-03), p. 797-807
    Type of Medium: Online Resource
    ISSN: 2164-5515 , 2164-554X
    URL: Article
    DOI: 10.4161/hv.27449
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2664177-X
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  • 2
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    Online Resource
    Spectral Enclosure and Superconvergence for Eigenvalues in Gaps
    Springer Science and Business Media LLC ; 2016
    In:  Integral Equations and Operator Theory Vol. 84, No. 1 ( 2016-1), p. 1-32
    Details
    In: Integral Equations and Operator Theory, Springer Science and Business Media LLC, Vol. 84, No. 1 ( 2016-1), p. 1-32
    Type of Medium: Online Resource
    ISSN: 0378-620X , 1420-8989
    URL: Article
    DOI: 10.1007/s00020-015-2247-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2111640-4
    SSG: 17,1
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  • 3
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    Online Resource
    Increased mitochondrial coupling and anaerobic capacity minimizes aerobic costs of trout in the sea
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-03-31)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-03-31)
    Abstract: Anadromy is a distinctive life-history strategy in fishes that has evolved independently many times. In an evolutionary context, the benefits of anadromy for a species or population must outweigh the costs and risks associated with the habitat switch. The migration of fish across the freshwater-ocean boundary coincides with potentially energetically costly osmoregulatory modifications occurring at numerous levels of biological organization. By integrating whole animal and sub-cellular metabolic measurements, this study presents significant findings demonstrating how an anadromous salmonid ( i.e. rainbow trout, Oncorhynchus mykiss ) is able to transform from a hyper- to hypo-osmoregulatory state without incurring significant increases in whole animal oxygen consumption rate. Instead, underlying metabolic mechanisms that fuel the osmoregulatory machinery at the organ level ( i.e. intestine) are modulated, as mitochondrial coupling and anaerobic metabolism are increased to satisfy the elevated energetic demands. This may have positive implications for the relative fitness of the migrating individual, as aerobic capacity may be maintained for locomotion ( i.e. foraging and predator avoidance) and growth. Furthermore, the ability to modulate mitochondrial metabolism in order to maintain osmotic balance suggests that mitochondria of anadromous fish may have been a key target for natural selection, driving species adaptations to different aquatic environments.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep45778
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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  • 4
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    Online Resource
    Mathematical Modeling and Optimization of Drug Delivery from Intratumorally Injected Microspheres
    American Association for Cancer Research (AACR) ; 2005
    In:  Clinical Cancer Research Vol. 11, No. 2 ( 2005-01-15), p. 826-834
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 11, No. 2 ( 2005-01-15), p. 826-834
    Abstract: Purpose: Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel to the whole tumor at different loads and rates has already been achieved, determining an optimal release mode of paclitaxel for tumor eradication remains difficult. This study set out to rationally design such an optimal microsphere release mode based on mathematical modeling. Experimental Design: A computational reaction-diffusion framework was used to model drug release from intratumorally injected microspheres, drug transport and binding in tumor interstitum, and drug clearance by microvasculature and intracellular uptake and binding. Results: Numerical simulations suggest that interstitial drug concentration is characterized by a fast spatially inhomogeneous rise phase, during which interstitial and intracellular binding sites are saturated, followed by a slow spatially homogeneous phase that is governed by the rate of drug release from microspheres. For zero-order drug release, the slow phase corresponds to a plateau drug concentration that is proportional to the ratio of the rate of blood clearance of drug to the rate of drug release from microspheres. Consequently, increasing the duration of intratumoral drug release extends the duration of cell exposure to the drug but lowers the plateau drug concentration. This tradeoff implies that intratumoral drug release can be designed to optimize tumor cell kill. Synthesizing our modeling predictions with published dose-response data, we propose an optimal protocol for the delivery of paclitaxel-loaded microspheres to small solid tumors.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1078-0432.826.11.2
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2005
    detail.hit.zdb_id: 1225457-5
    detail.hit.zdb_id: 2036787-9
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  • 5
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    Online Resource
    A60: Optic Nerve and Retinal Features in Uveitis Associated With Juvenile Systemic Granulomatous Disease (Blau Syndrome)
    Wiley ; 2014
    In:  Arthritis & Rheumatology Vol. 66, No. S3 ( 2014-03)
    Details
    In: Arthritis & Rheumatology, Wiley, Vol. 66, No. S3 ( 2014-03)
    Abstract: Juvenile systemic granulomatous disease (JSGD), also known as Blau syndrome, is a dominantly‐inherited autoinflammatory disorder associated with gain‐of‐function mutations in the NOD2 gene. The aim of this study was to determine whether patients with JSGD and uveitis have a specific ocular phenotype. Methods: Clinical and imaging data were collected retrospectively from patients attending the Regional Combined Paediatric Rheumatology and Ocular Inflammatory Service, Bristol Eye Hospital. General demographic information, laterality of the uveitis, age at onset, anatomical classification and course of the uveitis, clinical phenotype, and specific NOD2 mutation were recorded for each patient. All data were recorded in a database designed in Microsoft® Access®. Statistical analysis was performed using SPSS 20.0 (Cary, NC). Results: Seventeen eyes from 9 patients (5 males; 4 females) were included in the study. Mean age at the disease onset was 15 months; range 1–84 months. Eight patients had bilateral uveitis. Anterior uveitis was present in five eyes, intermediate uveitis in 2 eyes and there were 10 eyes with panuveitis, manifesting as multifocal choroiditis. Appearance of optic disc included indistinct disc margins in 6 eyes, optic nerve head palor in 6 eyes and optic disc vessels sheathing in 4 eyes. Fundal appearance included peripapillary hypo/hyperpigmention in 13 eyes accompanied with characteristic peripapillary nodular excrescences. Among NOD2 mutations, the p.R334W was the most commonly detected (n: 4 cases) and three patients carried novel variants, the p.E338D and p.D390V variants in one patient, and the p.H520Y and p.Q809K variants in two different patients. Conclusion: Chronic bilateral panuveitis and a nodular peripapillary appearance in childhood onset uveitis are characteristic features of JSGD, which support the need for an appropriate genetic NOD2 analysis.
    Type of Medium: Online Resource
    ISSN: 2326-5191 , 2326-5205
    URL: Issue
    URL: Article
    DOI: 10.1002/art.v66.S3
    DOI: 10.1002/art.38476
    RVK:
    XA 10000
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2754614-7
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  • 6
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    Book Reviews
    Intellect ; 2002
    In:  European Journal of American Culture Vol. 21, No. 1 ( 2002-04-01), p. 34-58
    Details
    In: European Journal of American Culture, Intellect, Vol. 21, No. 1 ( 2002-04-01), p. 34-58
    Abstract: Michael Manheim (ed.), The Cambridge Companion to Eugene O'Neill . Cambridge: Cambridge University Press, 1998, xviii + 256 pp., ISBN 0-521-55645-7 (paperback) William W. Demastes, Theatre of Chaos: Beyond Absurdism, Into Orderly Disorder . Cambridge: Cambridge University Press, 1998, 190 pp., ISBN 0-521-58245-8 (Hardback) 35 Andrew Pepper, The Contemporary American Crime Novel: Race, Ethnicity, Gender, Class , Edinburgh University Press, 2000, ISBN 0-7486-1340-4 (paperback) Michel Delville and Christine Pagnoulle (eds.), The Mechanics of the Mirage: Postwar American Poetry . Lige: Lige Language and Literature, 2000, 320 pp., ISBN 2-87233-025-9 (Paperback) 30 Paul Baepler (ed.), White Slaves, African Masters: An Anthology of American Barbary Captivity Narratives , Chicago: University of Chicago Press, 1999, ISBN 0-226-03403-8 (Hardback) 36.75, and 0-226-03404-6 (Paperback) 15.25 Ward H. Lamon, The Life of Abraham Lincoln: from his birth to his inauguration as President , Lincoln: University of Nebraska Press, 1999, 592 pp., ISBN 0-8032-7985-X, (Paperback) 14.95 Cornelis A. Van Minnen and Sylvia L. Hilton (eds.), Federalism, Citizenship, and Collective Identities in US History , Amsterdam: VU University Press, 2000, ii + 271 pp., ISBN 90-5383-714-0 (Paperback) 42.50 Patricia Merivale and Susan Elizabeth Sweeney (eds.), Detecting Texts: The Metaphysical Detective Story from Poe to Postmodernism , Philadelphia, Pennsylvania: University of Pennsylvania Press, 1999, 304 pp., ISBN 0-8122-3434-0 (paperback) 15.50 Joe Moran, Star Authors: Literary Celebrity in America , London: Pluto Press, 2000, 192 pp., ISBN 0-7453-1524 0 (hardback), 45.00, ISBN 0-7453-1519 4 (paperback) 14.99 John Tallmadge and Henry Harrington, (eds.), Reading Under the Sign of Nature: New Essays in Ecocriticism , Salt Lake City: University of Utah Press, 2000, xv + 368 pp., ISBN 0-87480-648-8 (paperback) 24.95 Bryan LeBeau, Religion in America to 1865 , Edinburgh: Edinburgh Univer sity Press, 2000, vi + 209 pp., ISBN 1-85331-233-9 (paperback) 12.95 Elizabeth Young, Disarming the Nation: Women's Writing and the American Civil War , Chicago and London: University of Chicago Press, 1999, xvi + 390 pp., ISBN 0-226-96087-0 (hardback) 33.00, ISBN 0-226-96088-9 (paperback) 13.00 Nancy A. Walker, (ed.), What's So Funny: Humor in American Culture , Wilmington, DE: Scholarly Resources, 1998, xi + 284 pp., ISBN 0-8420-2687-8 (hardback) 55.00, ISBN 0-8420-2688-6 (paperback) 17.95 Lisa M. Cuklanz, Rape on Prime Time: Television, Masculinity, and Sexual Violence , Philadelphia: University of Pennsylvania Press, 1999, 176 pp., ISBN 0-8122-3522-3 (hardback) 33.50, ISBN 0-8122-1710-1 (paperback) 11.95 Jill Andresky Fraser, White-Collar Sweatshop: The Deterioration of Work and Its Rewards in Corporate America , New York and London: W.W. Norton and Co., 2001, 278 pp., ISBN 0-393-04829-2 (hardback) 18.86 David Brauner, Post-War Jewish Fiction: Ambivalence, Self-Explanation and Transatlantic Connections , Hampshire and New York: Palgrave, 2001, ix + 222 pp., ISBN 0-333-74035-1 (hardback) 45.00. James P. Leary, (ed.), Wisconsin Folklore , Madison: University of Wisconsin Press, 1998, 543 pp., (paperback) 19.95, (hardback) 49.95 Rosella Mamoli Zorzi (ed.), Before Peggy Guggenheim: American Women Art Collectors , Departments of Anglo-American and Latin-American Studies, University Ca'Foscari of Venice, Marsilio, 2001, 254 pp., 17 b & w illus., ISBN 88-317-7737-8 (paperback)
    Type of Medium: Online Resource
    ISSN: 1466-0407 , 1758-9118
    URL: Article
    DOI: 10.1386/ejac.21.1.34
    Language: English
    Publisher: Intellect
    Publication Date: 2002
    SSG: 7,26
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  • 7
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    Online Resource
    High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples
    Oxford University Press (OUP) ; 2011
    In:  Clinical Chemistry Vol. 57, No. 11 ( 2011-11-01), p. 1545-1555
    Details
    In: Clinical Chemistry, Oxford University Press (OUP), Vol. 57, No. 11 ( 2011-11-01), p. 1545-1555
    Abstract: With expanding biomarker discovery efforts and increasing costs of drug development, it is critical to maximize the value of mass-limited clinical samples. The main limitation of available methods is the inability to isolate and analyze, from a single sample, molecules requiring incompatible extraction methods. Thus, we developed a novel semiautomated method for tissue processing and tissue milling and division (TMAD). METHODS We used a SilverHawk atherectomy catheter to collect atherosclerotic plaques from patients requiring peripheral atherectomy. Tissue preservation by flash freezing was compared with immersion in RNAlater®, and tissue grinding by traditional mortar and pestle was compared with TMAD. Comparators were protein, RNA, and lipid yield and quality. Reproducibility of analyte yield from aliquots of the same tissue sample processed by TMAD was also measured. RESULTS The quantity and quality of biomarkers extracted from tissue prepared by TMAD was at least as good as that extracted from tissue stored and prepared by traditional means. TMAD enabled parallel analysis of gene expression (quantitative reverse-transcription PCR, microarray), protein composition (ELISA), and lipid content (biochemical assay) from as little as 20 mg of tissue. The mean correlation was r = 0.97 in molecular composition (RNA, protein, or lipid) between aliquots of individual samples generated by TMAD. We also demonstrated that it is feasible to use TMAD in a large-scale clinical study setting. CONCLUSIONS The TMAD methodology described here enables semiautomated, high-throughput sampling of small amounts of heterogeneous tissue specimens by multiple analytical techniques with generally improved quality of recovered biomolecules.
    Type of Medium: Online Resource
    ISSN: 0009-9147 , 1530-8561
    URL: Article
    DOI: 10.1373/clinchem.2010.157743
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
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  • 8
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    Online Resource
    A study of Chitosan and c‐di‐GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine
    Wiley ; 2013
    In:  Influenza and Other Respiratory Viruses Vol. 7, No. 6 ( 2013-11), p. 1181-1193
    Details
    In: Influenza and Other Respiratory Viruses, Wiley, Vol. 7, No. 6 ( 2013-11), p. 1181-1193
    Abstract: Please cite this paper as: Svindland et al. (2012) A study of Chitosan and c‐di‐GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine. Influenza and Other Respiratory Viruses 10.1111/irv.12056000(000), 000–000. Background  Highly pathogenic avian influenza A/H5N1 virus remains a potential pandemic threat, and it is essential to continue vaccine development against this subtype. A local mucosal immune response in the upper respiratory tract may stop influenza transmission. It is therefore important to develop effective intranasal pandemic influenza vaccines that induce mucosal immunity at the site of viral entry. Objectives  We evaluated the humoral and cellular immune responses of two promising mucosal adjuvants (Chitosan and c‐di‐GMP) for intranasal influenza H5N1 vaccine in a murine model. Furthermore, we evaluated the concept of co‐adjuvanting an experimental adjuvant (c‐di‐GMP) with chitosan. Methods  BALB/c mice were intranasally immunised with two doses of subunit NIBRG‐14 (H5N1) vaccine (7·5, 1·5 or 0·3 μg haemagglutinin (HA) adjuvanted with chitosan (CSN), c‐di‐GMP or both adjuvants. Results  All adjuvant formulations improved the serum and local antibody responses, with the highest responses observed in the 7·5 μg HA CSN and c‐di‐GMP‐adjuvanted groups. The c‐di‐GMP provided dose sparing with protective single radial haemolysis (SRH), and haemagglutination inhibition (HI) antibody responses found in the 0·3 μg HA group. CSN elicited a Th2 response, whereas c‐di‐GMP induced higher frequencies of virus‐specific CD4 + T cells producing one or more Th1 cytokines (IFN‐γ + , IL‐2 + , TNF‐α + ). A combination of the two adjuvants demonstrated effectiveness at 7·5 μg HA and triggered a more balanced Th cytokine profile. Conclusion  These data show that combining adjuvants can modulate the Th response and in combination with ongoing studies of adjuvanted intranasal vaccines will dictate the way forward for optimal mucosal influenza vaccines.
    Type of Medium: Online Resource
    ISSN: 1750-2640 , 1750-2659
    URL: Issue
    URL: Article
    DOI: 10.1111/irv.2013.7.issue-6
    DOI: 10.1111/irv.12056
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2272349-3
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  • 9
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    Online Resource
    Further validation of the affective bias test for predicting antidepressant and pro-depressant risk
    Springer Science and Business Media LLC ; 2019
    In:  Pharmacological Reports Vol. 71, No. 6 ( 2019-12), p. 1310-
    Details
    In: Pharmacological Reports, Springer Science and Business Media LLC, Vol. 71, No. 6 ( 2019-12), p. 1310-
    Type of Medium: Online Resource
    ISSN: 1734-1140
    URL: Article
    DOI: 10.1016/j.pharep.2019.09.007
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2129019-2
    SSG: 15,3
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  • 10
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    Online Resource
    CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo
    Rockefeller University Press ; 1997
    In:  The Journal of Cell Biology Vol. 138, No. 2 ( 1997-07-28), p. 385-393
    Details
    In: The Journal of Cell Biology, Rockefeller University Press, Vol. 138, No. 2 ( 1997-07-28), p. 385-393
    Abstract: Through association with CDK1, cyclin B accumulation and destruction govern the G2/M/G1 transitions in eukaryotic cells. To identify CDK1 inactivation-dependent events during late mitosis, we expressed a nondestructible form of cyclin B (cyclin BΔ90) by microinjecting its mRNA into prometaphase normal rat kidney cells. The injection inhibited chromosome decondensation and nuclear envelope formation. Chromosome disjunction occurred normally, but anaphase-like movement persisted until the chromosomes reached the cell periphery, whereupon they often somersaulted and returned to the cell center. Injection of rhodamine-tubulin showed that this movement occurred in the absence of a central anaphase spindle. In 82% of cells cytokinesis was inhibited; the remainder split themselves into two parts in a process reminiscent of Dictyostelium cytofission. In all cells injected, F-actin and myosin II were diffusely localized with no detectable organization at the equator. Our results suggest that a primary effect of CDK1 inactivation is on spindle dynamics that regulate chromosome movement and cytokinesis. Prolonged CDK1 activity may prevent cytokinesis through inhibiting midzone microtubule formation, the behavior of proteins such as TD60, or through the phosphorylation of myosin II regulatory light chain.
    Type of Medium: Online Resource
    ISSN: 0021-9525 , 1540-8140
    URL: Article
    DOI: 10.1083/jcb.138.2.385
    RVK:
    WA 15000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 1997
    detail.hit.zdb_id: 1421310-2
    SSG: 12
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