In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 10 ( 2021-10-6), p. e0257807-
Abstract:
Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19 th March 2020 and 18 th May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized . In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1–2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0257807
DOI:
10.1371/journal.pone.0257807.g001
DOI:
10.1371/journal.pone.0257807.g002
DOI:
10.1371/journal.pone.0257807.g003
DOI:
10.1371/journal.pone.0257807.g004
DOI:
10.1371/journal.pone.0257807.t001
DOI:
10.1371/journal.pone.0257807.t002
DOI:
10.1371/journal.pone.0257807.t003
DOI:
10.1371/journal.pone.0257807.t004
DOI:
10.1371/journal.pone.0257807.s001
DOI:
10.1371/journal.pone.0257807.r001
DOI:
10.1371/journal.pone.0257807.r002
DOI:
10.1371/journal.pone.0257807.r003
DOI:
10.1371/journal.pone.0257807.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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