In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 8 ( 2023-8-17), p. e0290329-
Abstract:
Colonoscopy is necessary for diagnosing and surveilling patients with ulcerative colitis, though it may cause disease flares. Colonoscopy with carbon dioxide (CO 2 ) insufflation decreases abdominal discomfort; however, its effect on exacerbation incidence in ulcerative colitis remains unclear. Therefore, this study aimed to evaluate the colonoscopy effects using CO 2 insufflation in patients with ulcerative colitis. Methods Overall, 96 remissive patients with ulcerative colitis (partial Mayo score ≤ 2) who underwent total colonoscopy between March 2015 and December 2019 at Osaka University Hospital were enrolled and blindly randomized to the CO 2 (n = 45) and air (n = 51) insufflation group (UMIN-CTR, number: UMIN000018801). The post-procedural abdominal discomfort and the clinical relapse (partial Mayo score ≥ 3) rate within 8 weeks were evaluated. Results Baseline backgrounds did not differ between the groups. The mean abdominal fullness and pain scores were significantly lower in the CO 2 group than in the Air group immediately ( p = 0.0003, p = 0.0003) and 30 min ( p 〈 0.0001, p 〈 0.0001) after colonoscopy. While the overall clinical relapse rate remained unchanged between the groups, the clinical relapse rate at 8 weeks after colonoscopy was significantly lower in the CO 2 group than in the Air group in patients not in complete remission (Mayo endoscopic subscore ≥ 1, p = 0.049; or partial Mayo score ≥ 1, p = 0.022). Conclusions CO 2 insufflation can reduce abdominal discomfort in remissive patients with ulcerative colitis and decrease clinical relapse at 8 weeks after colonoscopy for those not in complete remission.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0290329
DOI:
10.1371/journal.pone.0290329.g001
DOI:
10.1371/journal.pone.0290329.g002
DOI:
10.1371/journal.pone.0290329.g003
DOI:
10.1371/journal.pone.0290329.g004
DOI:
10.1371/journal.pone.0290329.t001
DOI:
10.1371/journal.pone.0290329.t002
DOI:
10.1371/journal.pone.0290329.t003
DOI:
10.1371/journal.pone.0290329.s001
DOI:
10.1371/journal.pone.0290329.s002
DOI:
10.1371/journal.pone.0290329.s003
DOI:
10.1371/journal.pone.0290329.s004
DOI:
10.1371/journal.pone.0290329.r001
DOI:
10.1371/journal.pone.0290329.r002
DOI:
10.1371/journal.pone.0290329.r003
DOI:
10.1371/journal.pone.0290329.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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