In:
International Journal of Cancer, Wiley, Vol. 146, No. 6 ( 2020-03-15), p. 1618-1630
Abstract:
What's new? Pancreatic cancer is the fifth leading cause of cancer‐related deaths worldwide, with a five‐year survival rate of just 6 %. Thus, new therapeutic approaches are urgently needed. Here, targeting of the protein MALT1 with either biperiden or mepazine inhibited the growth of pancreatic ductal adenocarcinoma (PDAC) cells and increased PDAC cell apoptosis in vitro and in vivo . Analyses showed MALT1 to be expressed in the majority of pancreatic cancer cells, while lacking in healthy tissue. The data identify MALT1 as a novel therapeutic target in PDAC and identify biperiden and mepazine as promising therapeutic agents for the disease.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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