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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Kato, Norihiro ; BIOS-consortium ; Loh, Marie ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Nature Genetics Vol. 47, No. 11 ( 2015-11), p. 1282-1293

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 47, No. 11 ( 2015-11), p. 1282-1293

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3405

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 1494946-5

SSG: 12

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The role of positive selection in determining the molecular cause of species differences in disease

Vamathevan, Jessica J ; Hasan, Samiul ; Emes, Richard D ; [et al.]

Springer Science and Business Media LLC ; 2008

In: BMC Evolutionary Biology Vol. 8, No. 1 ( 2008-12)

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In: BMC Evolutionary Biology, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2008-12)

Abstract: Related species, such as humans and chimpanzees, often experience the same disease with varying degrees of pathology, as seen in the cases of Alzheimer's disease, or differing symptomatology as in AIDS. Furthermore, certain diseases such as schizophrenia, epithelial cancers and autoimmune disorders are far more frequent in humans than in other species for reasons not associated with lifestyle. Genes that have undergone positive selection during species evolution are indicative of functional adaptations that drive species differences. Thus we investigate whether biomedical disease differences between species can be attributed to positively selected genes. Results We identified genes that putatively underwent positive selection during the evolution of humans and four mammals which are often used to model human diseases (mouse, rat, chimpanzee and dog). We show that genes predicted to have been subject to positive selection pressure during human evolution are implicated in diseases such as epithelial cancers, schizophrenia, autoimmune diseases and Alzheimer's disease, all of which differ in prevalence and symptomatology between humans and their mammalian relatives. In agreement with previous studies, the chimpanzee lineage was found to have more genes under positive selection than any of the other lineages. In addition, we found new evidence to support the hypothesis that genes that have undergone positive selection tend to interact with each other. This is the first such evidence to be detected widely among mammalian genes and may be important in identifying molecular pathways causative of species differences. Conclusion Our dataset of genes predicted to have been subject to positive selection in five species serves as an informative resource that can be consulted prior to selecting appropriate animal models during drug target validation. We conclude that studying the evolution of functional and biomedical disease differences between species is an important way to gain insight into their molecular causes and may provide a method to predict when animal models do not mirror human biology.

Type of Medium: Online Resource

ISSN: 1471-2148

URL: Article

DOI: 10.1186/1471-2148-8-273

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2008

detail.hit.zdb_id: 2041493-6

detail.hit.zdb_id: 3053924-9

SSG: 12

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Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk

Qiu, Anqi ; Shen, Mojun ; Buss, Claudia ; [et al.]

Oxford University Press (OUP) ; 2017

In: Cerebral Cortex Vol. 27, No. 5 ( 2017-05-01), p. 3080-3092

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In: Cerebral Cortex, Oxford University Press (OUP), Vol. 27, No. 5 ( 2017-05-01), p. 3080-3092

Type of Medium: Online Resource

ISSN: 1047-3211 , 1460-2199

URL: Article

DOI: 10.1093/cercor/bhx065

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2017

detail.hit.zdb_id: 1483485-6

SSG: 12

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Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study

Chong, Yap-Seng ; Cai, Shirong ; Lin, Harvard ; [et al.]

Springer Science and Business Media LLC ; 2014

In: BMC Pregnancy and Childbirth Vol. 14, No. 1 ( 2014-12)

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In: BMC Pregnancy and Childbirth, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2014-12)

Type of Medium: Online Resource

ISSN: 1471-2393

URL: Article

DOI: 10.1186/1471-2393-14-345

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2059869-5

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Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour

Lillycrop, Karen A ; Costello, Paula M ; Teh, Ai Ling ; [et al.]

Oxford University Press (OUP) ; 2015

In: International Journal of Epidemiology Vol. 44, No. 4 ( 2015-08), p. 1263-1276

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In: International Journal of Epidemiology, Oxford University Press (OUP), Vol. 44, No. 4 ( 2015-08), p. 1263-1276

Type of Medium: Online Resource

ISSN: 0300-5771 , 1464-3685

URL: Article

DOI: 10.1093/ije/dyv052

RVK:

XF 4100

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2015

detail.hit.zdb_id: 1494592-7

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Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

Lillycrop, Karen A. ; EpiGen Consortium ; Garratt, Emma S. ; [et al.]

Springer Science and Business Media LLC ; 2019

In: International Journal of Obesity Vol. 43, No. 5 ( 2019-5), p. 974-988

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In: International Journal of Obesity, Springer Science and Business Media LLC, Vol. 43, No. 5 ( 2019-5), p. 974-988

Type of Medium: Online Resource

ISSN: 0307-0565 , 1476-5497

URL: Article

DOI: 10.1038/s41366-018-0254-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2101927-7

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Transcriptome Changes Affecting Hedgehog and Cytokine Signalling in the Umbilical Cord: Implications for Disease Risk

Stünkel, Walter ; Pan, Hong ; Chew, Siew Boom ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 7 ( 2012-7-10), p. e39744-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 7 ( 2012-7-10), p. e39744-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0039744

DOI: 10.1371/journal.pone.0039744.g001

DOI: 10.1371/journal.pone.0039744.g002

DOI: 10.1371/journal.pone.0039744.g003

DOI: 10.1371/journal.pone.0039744.g004

DOI: 10.1371/journal.pone.0039744.g005

DOI: 10.1371/journal.pone.0039744.t001

DOI: 10.1371/journal.pone.0039744.t002

DOI: 10.1371/journal.pone.0039744.s001

DOI: 10.1371/journal.pone.0039744.s002

DOI: 10.1371/journal.pone.0039744.s003

DOI: 10.1371/journal.pone.0039744.s004

DOI: 10.1371/journal.pone.0039744.s005

DOI: 10.1371/journal.pone.0039744.s006

DOI: 10.1371/journal.pone.0039744.s007

DOI: 10.1371/journal.pone.0039744.s008

DOI: 10.1371/journal.pone.0039744.s009

DOI: 10.1371/journal.pone.0039744.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells

Sukarieh, Rami ; Joseph, Roy ; Leow, Shi Chi ; [et al.]

Oxford University Press (OUP) ; 2014

In: Human Reproduction Vol. 29, No. 10 ( 2014-10-10), p. 2287-2301

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In: Human Reproduction, Oxford University Press (OUP), Vol. 29, No. 10 ( 2014-10-10), p. 2287-2301

Type of Medium: Online Resource

ISSN: 1460-2350 , 0268-1161

URL: Article

DOI: 10.1093/humrep/deu209

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2014

detail.hit.zdb_id: 1484864-8

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Choice of surrogate tissue influences neonatal EWAS findings

Lin, Xinyi ; Teh, Ai Ling ; Chen, Li ; [et al.]

Springer Science and Business Media LLC ; 2017

In: BMC Medicine Vol. 15, No. 1 ( 2017-12)

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In: BMC Medicine, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2017-12)

Type of Medium: Online Resource

ISSN: 1741-7015

URL: Article

DOI: 10.1186/s12916-017-0970-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2131669-7

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Fetal DNA methylation of cortisol-related genes and infant neurobehavior at 6 months: The role of antenatal maternal anxiety

Tsotsi, Stella ; Abdulla, Nurshuhadah ; Li, Chen ; [et al.]

Elsevier BV ; 2015

In: Psychoneuroendocrinology Vol. 61 ( 2015-11), p. 35-

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In: Psychoneuroendocrinology, Elsevier BV, Vol. 61 ( 2015-11), p. 35-

Type of Medium: Online Resource

ISSN: 0306-4530

URL: Article

DOI: 10.1016/j.psyneuen.2015.07.484

RVK:

YH 2600

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 1500706-6

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