In:
Lipids, Wiley, Vol. 28, No. 9 ( 1993-09), p. 811-817
Abstract:
The effect of dietary α‐linolenic acid (18∶3n−3) and its ratio to linoleic acid (18∶2n−6) on platelet and plasma phospholipid (PL) fatty acid patterns and prostanoid production were studied in normolipidemic men. The study consisted of two 42‐d phases. Each was divided into a 6‐d pre‐experimental period, during which a mixed fat diet was fed, and two 18‐d experimental periods, during which a mixture of sunflower and olive oil [low 18∶3n−3 content, high 18∶2/18∶3 ratio (LO‐HI diet)], soybean oil (intermediate 18∶3n−3 content, intermediate 18∶2/18∶3 ratio), canola oil (intermediate 18∶3n−3 content, low 18∶2/18∶3 ratio) and a mixture of sunflower, olive and flax oil [high 18∶3n−3 content, low 18∶2/18∶3 ratio (HI‐LO diet)] provided 77% of the fat (26% of the energy) in the diet. The 18∶3n−3 content and the 18∶2/18∶3 ratio of the experimental diets were: 0.8%, 27.4; 6.5%, 6.9; 6.6%, 3.0; and 13.4%, 2.7, respectively. There were appreciable differences in the fatty acid composition of platelet and plasma PLs. Nevertheless, 18∶1n−9, 18∶2n−6 and 18∶3n−3 levels in PL reflected the fatty acid composition of the diets, although very little 18∶3n−3 was incorporated into PL. Both the level of 18∶3n−3 in the diet and the 18∶2/18∶3 ratio were important in influencing the levels of longer chain n−3 fatty acid, especially 20∶5n−3, in platelet and plasma PL. Production of 6‐keto‐PGF 1α was significantly ( P 〈 0.05) higher following the HI‐LO diet than the LO‐HI diet although dietary fat source had no effect on bleeding time or thromboxane B 2 production. The present study showed that both the level of 18∶3n−3 in the diet and its ratio to 18∶2n−6 were important in influencing long‐chain n−3 fatty acid levels in platelet and plasma PL and that prostanoid production coincided with the diet‐induced differences in PL fatty acid patterns.
Type of Medium:
Online Resource
ISSN:
0024-4201
,
1558-9307
Language:
English
Publisher:
Wiley
Publication Date:
1993
detail.hit.zdb_id:
2030265-4
SSG:
12
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