In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 10 ( 2023-10-9), p. e0292591-
Abstract:
We study factors affecting neutrophil-to-lymphocyte ratio (NLR) and its changes throughout the treatment (ΔNLR) of nasopharyngeal carcinoma (NPC) underwent chemoradiotherapy (CCRT) followed by adjuvant chemotherapy (AC) and oncological outcomes including overall survival (OS) and disease-free survival (DFS). Methods Data from 81 NPC patients was retrospectively evaluated. NLRs were obtained from first week of CCRT (pre-CCRT), last week of CCRT (end-CCRT), and at last cycle of AC (end-AC). Pre-CCRT NLR was categorized into “low” and “high”. End-CCRT and end-AC ΔNLRs were divided into “increased” and “decreased” based on NLR at these two timepoints relative to the value at pre-CCRT. Associations between sex, age, cancer stage and NLR, ΔNLRs were investigated. OS and DFS were reported. Results Median NLR at pre-CCRT (2.47) was lower than NLR at end-CCRT (6.29) and end-AC (3.77) ( P -value = 0.043). Advanced cancer stage associated with high pre-CCRT NLR ( P -value = 0.047). Male gender was associated with "increased" end-CCRT ΔNLR, whereas male gender and age ≤51 were associated with "increased" end-AC ΔNLR. Three-year OS and DFS rates were 85.25% and 76.39%, respectively. There were no statistically significant differences observed in OS and DFS among groups categorized by pre-CCRT NLR, ΔNLRs, gender, age, and cancer stage. Conclusions NLR increases during NPC treatment. Advanced staging is associated with higher baseline NLR. Increased ΔNLR is associated with male gender at end-CCRT and male gender with age ≤51 years at end-AC. No relation between NLR and its dynamic change with either OS or DFS was demonstrated.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0292591
DOI:
10.1371/journal.pone.0292591.g001
DOI:
10.1371/journal.pone.0292591.g002
DOI:
10.1371/journal.pone.0292591.g003
DOI:
10.1371/journal.pone.0292591.g004
DOI:
10.1371/journal.pone.0292591.t001
DOI:
10.1371/journal.pone.0292591.t002
DOI:
10.1371/journal.pone.0292591.t003
DOI:
10.1371/journal.pone.0292591.t004
DOI:
10.1371/journal.pone.0292591.t005
DOI:
10.1371/journal.pone.0292591.s001
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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