KOBV Portal

Hits per page

hits 1 - 10 | 151 hits

Sorting

Online Resource

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abaleke, Eugenia ; Abbas, Mustafa ; Abbasi, Sadia ; [et al.]

Elsevier BV ; 2021

In: The Lancet Vol. 397, No. 10274 ( 2021-02), p. 605-612

add to watchlist on the watchlist

Details

In: The Lancet, Elsevier BV, Vol. 397, No. 10274 ( 2021-02), p. 605-612

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(21)00149-5

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Edwards, Mark R. ; Forbes, Gordon ; Walker, Neil ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Trials Vol. 24, No. 1 ( 2023-05-06)

add to watchlist on the watchlist

Details

In: Trials, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-05-06)

Abstract: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy algorithms in patients undergoing gastrointestinal surgery have suggested this intervention results in reduced complications and a modest reduction in mortality. However, this existing evidence is based mainly on elective (planned) surgery, with little evaluation in the emergency setting. There are fundamental clinical and pathophysiological differences between the planned and emergency surgical setting which may influence the effects of this intervention. A large definitive trial in emergency surgery is needed to confirm or refute the potential benefits observed in elective surgery and to inform widespread clinical practice. Methods The FLO-ELA trial is a multi-centre, parallel-group, open, randomised controlled trial. 3138 patients aged 50 and over undergoing major emergency gastrointestinal surgery will be randomly allocated in a 1:1 ratio using minimisation to minimally invasive cardiac output monitoring to guide protocolised administration of intra-venous fluid, or usual care without cardiac output monitoring. The trial intervention will be carried out during surgery and for up to 6 h postoperatively. The trial is funded through an efficient design call by the National Institute for Health and Care Research Health Technology Assessment (NIHR HTA) programme and uses existing routinely collected datasets for the majority of data collection. The primary outcome is the number of days alive and out of hospital within 90 days of randomisation. Participants and those delivering the intervention will not be blinded to treatment allocation. Participant recruitment started in September 2017 with a 1-year internal pilot phase and is ongoing at the time of publication. Discussion This will be the largest contemporary randomised trial examining the effectiveness of perioperative cardiac output-guided haemodynamic therapy in patients undergoing major emergency gastrointestinal surgery. The multi-centre design and broad inclusion criteria support the external validity of the trial. Although the clinical teams delivering the trial interventions will not be blinded, significant trial outcome measures are objective and not subject to detection bias. Trial registration ISRCTN 14729158. Registered on 02 May 2017.

Type of Medium: Online Resource

ISSN: 1745-6215

URL: Article

DOI: 10.1186/s13063-023-07275-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2040523-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Van Voorhis, Wesley C. ; Adams, John H. ; Adelfio, Roberto ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS Pathogens Vol. 12, No. 7 ( 2016-7-28), p. e1005763-

add to watchlist on the watchlist

Details

In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 12, No. 7 ( 2016-7-28), p. e1005763-

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1005763

DOI: 10.1371/journal.ppat.1005763.g001

DOI: 10.1371/journal.ppat.1005763.g002

DOI: 10.1371/journal.ppat.1005763.t001

DOI: 10.1371/journal.ppat.1005763.t002

DOI: 10.1371/journal.ppat.1005763.s001

DOI: 10.1371/journal.ppat.1005763.s002

DOI: 10.1371/journal.ppat.1005763.s003

DOI: 10.1371/journal.ppat.1005763.s004

DOI: 10.1371/journal.ppat.1005763.s005

DOI: 10.1371/journal.ppat.1005763.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2205412-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A Randomised Controlled Double-Blind Study of Remote Ischaemic Preconditioning in High-Risk Cardiac Surgery

Young, Paul ; Mahon, Barry ; Dalley, Paul ; [et al.]

Elsevier BV ; 2013

In: Heart, Lung and Circulation Vol. 22, No. 6 ( 2013-6), p. 474-

add to watchlist on the watchlist

Details

In: Heart, Lung and Circulation, Elsevier BV, Vol. 22, No. 6 ( 2013-6), p. 474-

Type of Medium: Online Resource

ISSN: 1443-9506

URL: Article

DOI: 10.1016/j.hlc.2013.03.043

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 2026333-8

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A pilot study investigating the effects of remote ischemic preconditioning in high-risk cardiac surgery using a randomised controlled double-blind protocol

Young, Paul Jeffrey ; Dalley, Paul ; Garden, Alexander ; [et al.]

Springer Science and Business Media LLC ; 2012

In: Basic Research in Cardiology Vol. 107, No. 3 ( 2012-5)

add to watchlist on the watchlist

Details

In: Basic Research in Cardiology, Springer Science and Business Media LLC, Vol. 107, No. 3 ( 2012-5)

Type of Medium: Online Resource

ISSN: 0300-8428 , 1435-1803

URL: Article

DOI: 10.1007/s00395-012-0256-6

RVK:

XA 31125

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2012

detail.hit.zdb_id: 1458470-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Chloroquine Resistance Modulated in Vitro by Expression Levels of the Plasmodium falciparum Chloroquine Resistance Transporter

Waller, Karena L. ; Muhle, Rebecca A. ; Ursos, Lyann M. ; [et al.]

Elsevier BV ; 2003

In: Journal of Biological Chemistry Vol. 278, No. 35 ( 2003-08), p. 33593-33601

add to watchlist on the watchlist

Details

In: Journal of Biological Chemistry, Elsevier BV, Vol. 278, No. 35 ( 2003-08), p. 33593-33601

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M302215200

Language: English

Publisher: Elsevier BV

Publication Date: 2003

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum

Doerig, Caroline M. ; Parzy, Daniel ; Langsley, Gordon ; [et al.]

Elsevier BV ; 1996

In: Gene Vol. 177, No. 1-2 ( 1996-1), p. 1-6

add to watchlist on the watchlist

Details

In: Gene, Elsevier BV, Vol. 177, No. 1-2 ( 1996-1), p. 1-6

Type of Medium: Online Resource

ISSN: 0378-1119

URL: Article

DOI: 10.1016/0378-1119(96)00281-8

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 1996

detail.hit.zdb_id: 1491012-3

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Stage specific expression of proliferating cell nuclear antigen and DNA polymerase δ from Plasmodium falciparum

Horrocks, Paul ; Jackson, Mandy ; Cheesman, Sandie ; [et al.]

Elsevier BV ; 1996

In: Molecular and Biochemical Parasitology Vol. 79, No. 2 ( 1996-8), p. 177-182

add to watchlist on the watchlist

Details

In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 79, No. 2 ( 1996-8), p. 177-182

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/0166-6851(96)02657-6

Language: English

Publisher: Elsevier BV

Publication Date: 1996

detail.hit.zdb_id: 1491098-6

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Intraerythrocytic expression of topoisomerase II from Plasmodium falciparum is developmentally regulated

Cheesman, Sandie ; Horrocks, Paul ; Tosh, Kerrie ; [et al.]

Elsevier BV ; 1998

In: Molecular and Biochemical Parasitology Vol. 92, No. 1 ( 1998-4), p. 39-46

add to watchlist on the watchlist

Details

In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 92, No. 1 ( 1998-4), p. 39-46

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/S0166-6851(97)00223-5

Language: English

Publisher: Elsevier BV

Publication Date: 1998

detail.hit.zdb_id: 1491098-6

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

Doerig, Christian ; Doerig, Caroline ; Horrocks, Paul ; [et al.]

Elsevier BV ; 1995

In: Molecular and Biochemical Parasitology Vol. 70, No. 1-2 ( 1995-3), p. 167-174

add to watchlist on the watchlist

Details

In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 70, No. 1-2 ( 1995-3), p. 167-174

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/0166-6851(95)00033-W

Language: English

Publisher: Elsevier BV

Publication Date: 1995

detail.hit.zdb_id: 1491098-6

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 151 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg