In:
Archiv der Pharmazie, Wiley, Vol. 319, No. 4 ( 1986-01), p. 296-302
Abstract:
Pyrrolidine‐2,5‐diones with Basic Substituents, III: Anticonvulsant Activity of Racem, and Optically Active Pyrrolidine‐2,5‐diones with Basic Substituents The anticonvulsant activity of racem. and optically active pyrrolidinediones with basic substituents was determined in mice. Against seizures induced by electrical stimulation the racemates 1c–3c possess the same activity. Against convulsions caused by pentetrazol, compounds 2c and 3c protect 90% of the animals whereas compound 1c is inactive. The (+)‐enantiomer of 1b has a higher anticonvulsant activity than the (−)‐enantiomer. The enantiomers of 2a, 3a and 3b , too, show stereoselective differences in anticonvulsant activity. The (+)‐enantiomer of compound 1a possesses anticonvulsant activity, the (−)‐enantiomer, however, shows the highest toxicity of all the investigated pyrrolidinediones with basic substituents.
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.19863190403
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
1496815-0
SSG:
15,3
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