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  • 1
    In: Archives of Veterinary Medicine, Scientific Veterinary Institute 'Novi Sad', Vol. 11, No. 1 ( 2018-09-16), p. 79-90
    Abstract: West Nile virus (WNV) is arbovirus distributed all around the world. In humans, 80% of infection cases are asymptomatic. In 20% of infected people, a febrile self-limiting illness is reported. WNV has the potential for fatal neuroinvasive disease. In 1% of cases, the infection may result in neuroinvasive disease with permanent neurological consequences or death outcome. Neurological forms may vary presenting with encephalitis, meningitis, meningoencephalitis or acute flaccid paralysis. Outbreaks with neurological forms of WNV infection were recorded in different areas of Greece, Italy, Romania, Hungary and Serbia. During the period from 2013 to 2016, 114 samples of cerebrospinal fluid and 107 serum samples were taken from 114 patients suspected of WNV neuroinvasive disease (WNND). The presence of specific anti-WNV IgM and IgG antibodies in cerebrospinal fluid (CSF) and sera samples were tested by WNV IgM and IgG ELISA (Euroimmun, Germany). In addition, 48 samples of CSF or/and serum of people with suspected WNV infection were examined by commercial molecular tests - real time RT-PCR (WNV Real-TM, Sacace biotechnologies, Italy). The IgM antibodies against WNV were present in 25.4% (29/114) of CSF samples, and in 31.8% (34/107) of serum samples tested from 114 patients suspected of WNND. The IgG antibodies against WNV were detected in 3.5% (4/114) of CSF samples, and in 11.2% (12/107) of serum samples. The WNV RNA was detected by real time RT-PCR test in 7 out of 48 (14.6%) CSF or/and serum samples. In this study, detection of IgM antibodies in CSF is more frequent than detection of WNV RNA in CSF or serum samples. WNV RNA detection in CSF is confirmatory diagnostic test but has limited utility in the diagnosis of WNV neuroinvasive disease due to low viremia level at the time of clinical presentation of the disease. The limitations in the use of ELISA IgM test are linked to cross - reactivity among flaviviruses and long persistence of IgM antibodies in the serum and CSF.
    Type of Medium: Online Resource
    ISSN: 2683-4138 , 1820-9955
    Language: Unknown
    Publisher: Scientific Veterinary Institute 'Novi Sad'
    Publication Date: 2018
    detail.hit.zdb_id: 3036358-5
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  • 2
    Online Resource
    Online Resource
    National Library of Serbia ; 2016
    In:  Medical review Vol. 69, No. 3-4 ( 2016), p. 93-98
    In: Medical review, National Library of Serbia, Vol. 69, No. 3-4 ( 2016), p. 93-98
    Abstract: nema
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2016
    detail.hit.zdb_id: 2381028-2
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  • 3
    Online Resource
    Online Resource
    National Library of Serbia ; 2009
    In:  Medical review Vol. 62, No. 5-6 ( 2009), p. 231-235
    In: Medical review, National Library of Serbia, Vol. 62, No. 5-6 ( 2009), p. 231-235
    Abstract: Virus Zapadnog Nila je RNA virus iz porodice Flaviviridae. U zivotni ciklus virusa ukljuceni su komarci Culicine i divlje ptice. Covek kao slucajni domacin biva inficiran ubodom inficiranog komarca. Prenos sa coveka na coveka je moguc preko transfuzija krvi i krvnih produkata, transplantacijom, transplacentarno i dojenjem. Slucajevi infekcije kod ljudi zabelezeni su u Africi i Aziji. U Rumuniji je registrovana epidemija 1996. godine sa stotinama neuroloskih slucajeva i 17 smrtnih slucajeva. Prva epidemija u Americi registrovana je 1999. u Njujorku. Vecina slucajeva je bez simptoma. U slucaju manifestne infekcije simptomi su temperatura, slabost, mucnina, povracanje, izrazita mialgija, artralgija i glavobolja. Manje od 1% inficiranih ima teske neuroloske sindrome - meningitis, encefalitis ili flakcidnu paralizu. Dijagnoza se zasniva na seroloskim testovima (ELISA IgM iz seruma i likvora), na izolaciji virusa ili dokazivanju virusnih antigena ili virusnog genoma. Lecenje je simptomatsko. Prevencija se zasniva na integralnom istrazivanju prisustva virusa u vektorima, rezervoarima i ljudskoj populaciji, na merama za suzbijanje komaraca i na licnim zastitnim merama.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2009
    detail.hit.zdb_id: 2381028-2
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  • 4
    Online Resource
    Online Resource
    Scientific Veterinary Institute 'Novi Sad' ; 2011
    In:  Archives of Veterinary Medicine Vol. 4, No. 1 ( 2011-06-28), p. 11-18
    In: Archives of Veterinary Medicine, Scientific Veterinary Institute 'Novi Sad', Vol. 4, No. 1 ( 2011-06-28), p. 11-18
    Abstract: The objective of this paper is to emphasize the signifi cance of bacterial zoonoses in Vojvodina in the period 2005-2009. Th e study is based on data from the Health Statistical Yearbook of the Republic of Serbia published by the Institute of Public Health of Serbia “Dr Milan Jovanović Batut”. Bacterial zoonoses were represented with 1.16% (5610/482596) among the total number of registered bacterial zoonoses in Vojvodina 2005-2009. Among them the most frequent were salmonellosis with 62.83% (3525/5610). The incidence in Vojvodina in the period 2005-2009 ranged between 46.45-22.78 per 100,000 population. According to frequence Lyme disease was at second place with 19.20% (1077/5610) among the total number of registered bacterial zoonoses. Lyme disease in Vojvodina in the period 2005-2009 had an increasing trend: the number of reported cases increased from 164 in 2005 to 294 in 2009. According to the number of registered cases campylobacteriosis was at the third place - 794 cases (14.15%). Q fever was at the fourth place. Almost all cases of Q fever which were registered in Serbia, were from Vojvodina (92 of 93 cases). Other zoonoses in Vojvodina were represented with less than 2% of the total number of registered bacterial zoonoses: leptospirosis 1.10% (62/5610), brucellosis 0.48% (27/5610), tetanus 0.27% (15/5610), listeriosis 0.23% (13/5610), ornithosis 0.07% (4/5610), tularemia 0.02% (1/4816). The causative agents of bacterial zoonoses were important human pathogens in Vojvodina in the period 2005-2009. Among them the most common were Salmonella and Lyme disease.
    Type of Medium: Online Resource
    ISSN: 2683-4138 , 1820-9955
    Language: Unknown
    Publisher: Scientific Veterinary Institute 'Novi Sad'
    Publication Date: 2011
    detail.hit.zdb_id: 3036358-5
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  • 5
    In: Archives of Veterinary Medicine, Scientific Veterinary Institute 'Novi Sad', Vol. 12, No. 1 ( 2019-09-12), p. 33-41
    Abstract: Toxoplasma gondii is a ubiquitous coccidian protozoan that can infect a wide range of warm-blooded animals, including humans. For immunocompetent humans it is a well-adapted parasite that usually causes asymptomatic infection. However, in congenitally infected infants and immunocompromised patients it can cause a serious life threatening disease. The aim of this study was to determine the levels of anti-toxoplasma antibodies among residents of the South Backa District, Serbia. During the period from January 2014 to December 2018, sera from 11,288 persons from South Backa District were tested on the presence of IgM and IgG antibodies against Toxoplasma gondii, using ELISA test (Euroimmun, Lübeck, Germany). The testing was performed on the automatic device Euroimmun Analyzer I-2P. The avidity of IgG WNV antibodies was determined for IgG positive sera using commercial avidity test (Euroimmun, Lübeck, Germany). In total, out of 11,288 patients who were tested for toxoplasma antibodies, the results were positive for 2,513 (22.26%). In 2014 seropositivity for Toxoplasma gondii was 25.78% (464/1800), in 2015 it was 23.30% (400/1717), in 2016 it amounted 20.99% (474/2258), in 2017 it was 21.47% (529/2464) and in 2018 seropositivity was 20.96% (639/3049). Seropositivity of 26.53% (390/1470) was found in males and it amounted 21.62% (2123/9818) in females. Possible recent infection within the last 12 months was found in 1.70% (192/11288) patients. Possible acute infection or false - positive IgM result was detected in 1.31% (148/11288) patients. Past infection was found in 2173/11288 (19.25%) patients. Equivocal results were found in 1.48% of samples (167/11288). The lowest frequency of anti-toxoplasma antibodies was detected in pre-school children 13.07% (97/742) and the highest in persons older than 65 years 60.18% (65/108). Comparing the results of the research done from 2014 to 2018 with the data from 1989, a significant decline of seroprevalence in general population and women of generative age was found.
    Type of Medium: Online Resource
    ISSN: 2683-4138 , 1820-9955
    Language: Unknown
    Publisher: Scientific Veterinary Institute 'Novi Sad'
    Publication Date: 2019
    detail.hit.zdb_id: 3036358-5
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  • 6
    Online Resource
    Online Resource
    National Library of Serbia ; 2015
    In:  Medical review Vol. 68, No. 3-4 ( 2015), p. 122-125
    In: Medical review, National Library of Serbia, Vol. 68, No. 3-4 ( 2015), p. 122-125
    Abstract: Introduction. Chikungunya is a contagious disease caused by Chikungunya virus, an arbovirus from the Togaviridae family. This infection is mostly spread by mosquitoes from the genus Aedes, especially Aedes albopictus, which have spread from Asia to America and Europe including some countries surrounding Serbia. Epidemiologic Features. The outbreak of epidemics has been reported in Philippines, Sumatra, Java, Indonesia, West Africa region (from Senegal to Cameroon), Congo, Nigeria, Angola, Uganda, Guinea, Malawi, Central African Republic, Burundi, South Africa and India. At the beginning of the 21st century, large outbreaks were recorded on the island of R?union. During 2006, 1.400.000 cases of chikungunya infection were recorded in India. Local transmission of infection in continental Europe was reported from Northeast Italy (254 suspected and 78 laboratory confirmed cases in Emilia-Romagna region) and France (two cases in 2010). From December 2013 to June 2014, 5.294 confirmed cases and more than 180.000 suspected cases of chikungunya were reported in the Caribbean. Clinical Findings. The disease presents suddenly with fever, rush and arthralgia. In general, chikungunya is a mild self - limited disease. Less often, it may be presented with signs of meningoencephalitis or fulminant hepatitis, sometimes with fatal outcome. Conclusion. Fast developing international traffic and booming tourism as well as the vector spreading from its homeland make chikungunya a real threat to our country.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2015
    detail.hit.zdb_id: 2381028-2
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  • 7
    Online Resource
    Online Resource
    National Library of Serbia ; 2009
    In:  Medical review Vol. 62, No. 11-12 ( 2009), p. 583-586
    In: Medical review, National Library of Serbia, Vol. 62, No. 11-12 ( 2009), p. 583-586
    Abstract: Rod enterokoka obuhvata gram-pozitivne anaerobe koji su deo normalne flore razlicitih organskih sistema coveka. Enterokoki su uzrocnici infekcija najcesce kod imunokompromitovanih i osoba podvrgnutih endoskopskim i hirurskim intervencijama. Izazivaci su 5-10% svih endokarditisa. Klinicka slika enterokoknog endokarditisa ne razlikuje se od klinicke slike drugih bakterijskih endokarditisa. Izbor antibioterapije u lecenju enterokoknog endokarditisa zahteva prethodno ispitivanje osetljivosti izolata na antibiotike zbog rastuce rezistencije enterokoka. Spektar antibiotika efikasnih protiv enterokoka obuhvata ampicilin, vankomicin i aminoglikozide. Infekcije izazvane multirezistentnim E. fecalis lece se kombinacijom imipenema/cilastatina ili ceftriaksona s ampicilinom. U radu je prikazan slucaj mlade zenske osobe sa subakutnim bakterijskim endokarditisom izazvanim enterokokom koji se manifestovao protrahovanim febrilnim stanjem s visekratno pozitivnom hemokulturom. Vegetacije na mitralnom zalisku (izvor bakterijemije) pouzdano su verifikovane tek cetvrtim ehokardiografskin pregledom. Kombinacija antibiotske i hirurske terapije dovela je do povoljnog ishoda bolesti.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2009
    detail.hit.zdb_id: 2381028-2
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  • 8
    Online Resource
    Online Resource
    National Library of Serbia ; 2006
    In:  Medical review Vol. 59, No. 1-2 ( 2006), p. 29-32
    In: Medical review, National Library of Serbia, Vol. 59, No. 1-2 ( 2006), p. 29-32
    Abstract: Virus influence A inficira mnoge sisare i ptice koje su glavni rezervoar virusa u prirodi. Humani virusi influence A, uzrocnici pandemija u 20. veku. pripadaju podtipovima A(H1N1), A(H2N2) i A(H3N2). Pticji virusi influence su brojniji, sa svih 15 postojecih hemaglutinina i 9 neuraminidaza. Do sada su dokazane humane infekcije pticjim virusima influence A(H7N7), A(H5N1) i A(H9N2). Zbog velikog morbiditeta i teske klinicke slike najznacajnije su humane infekcije virusom A(H5N1). Humani slucajevi influence A(H5N1) proticu sa respiratornim simptomima, eventualno komplikacijama kao sto su pneumonija, respiratorni distres sindrom, insuficijencija jetre i bubrega i hematoloski poremecaji. Pticji virusi se prenose na ljude direktno. Analiza njihovog genoma ukazuje na iskljucivo pticje poreklo gena. Znacaj humanih infekcija pticjim virusima influence je u opasnosti da u coveku, pri istovremenoj infekciji humanim i pticjim virusima, dodje do rekombinacije humanih i pticjih gena i stvaranja novog podtipa virusa influence sa pandemijskim potencijalom i sposobnoscu interhumanog prenosa. .
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2006
    detail.hit.zdb_id: 2381028-2
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  • 9
    Online Resource
    Online Resource
    National Library of Serbia ; 2017
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 74, No. 6 ( 2017), p. 590-593
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 74, No. 6 ( 2017), p. 590-593
    Abstract: nema
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2017
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    National Library of Serbia ; 2002
    In:  Medical review Vol. 55, No. 9-10 ( 2002), p. 412-414
    In: Medical review, National Library of Serbia, Vol. 55, No. 9-10 ( 2002), p. 412-414
    Abstract: Cilj istrazivanja je bilo utvrdjivanje klinickih karakteristika preherpeticne neuralgije i njenog uticaja na pojavu postherpeticne neuralgije. Prospektivnim istrazivanjem obuhvaceno je 88 obolelih od herpes zostera sa preherpeticnom neuralgijom. Kontrolnu grupu cinila su 44 obolela od zostera bez preherpeticne neuralgije. Praceni su uzrast, pol, vrsta, intenzitet i trajanje preherpeticnog bola i ucestalost postherpeticne neuralgije. U statistickoj obradi rezultata koriscen je ?? test. Stariji od 60 godina (59,1%) signifikantno su cesce ispoljavali preherpeticnu neuralgiju u odnosu na ostale uzrasne grupe (??=37,09, p〈0,01), sto vazi i za zenski pol (59,9%) u odnosu na muski (??=37,09, p〈0,01). Registrovane su razlicite vrste preherpeticnog bola (probadi, pecenje, svrab, cupanje). Srednje trajanje preherpeticne neuralgije bilo je 4,4 dana (raspon 1-20 dana). Pojava i intenzitet preherpeticne neuralgije nisu uticali na pojavu postherpeticne neuralgije.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2002
    detail.hit.zdb_id: 2381028-2
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