In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2021-6-11), p. e1009618-
Abstract:
Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C . elegans , we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite extension. DAF-6 encodes a glia-specific patched-related membrane protein that plays vital roles in glial morphogenesis. We cloned dyf-4 and found that DYF-4 encodes a glia-secreted protein. Further investigations revealed that DYF-4 interacts with DAF-6 and functions in a same pathway as DAF-6 to regulate sensory compartment formation. Furthermore, we demonstrated that reported glial suppressors of daf-6 could also restore dendrite elongation and ciliogenesis in both dyf-4 and daf-6 mutants. Collectively, our data reveal that DYF-4 is a regulator for DAF-6 which promotes the proper formation of the glial channel and indirectly affects neurite extension and ciliogenesis.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009618
DOI:
10.1371/journal.pgen.1009618.g001
DOI:
10.1371/journal.pgen.1009618.g002
DOI:
10.1371/journal.pgen.1009618.g003
DOI:
10.1371/journal.pgen.1009618.g004
DOI:
10.1371/journal.pgen.1009618.g005
DOI:
10.1371/journal.pgen.1009618.g006
DOI:
10.1371/journal.pgen.1009618.g007
DOI:
10.1371/journal.pgen.1009618.g008
DOI:
10.1371/journal.pgen.1009618.s001
DOI:
10.1371/journal.pgen.1009618.s002
DOI:
10.1371/journal.pgen.1009618.s003
DOI:
10.1371/journal.pgen.1009618.s004
DOI:
10.1371/journal.pgen.1009618.s005
DOI:
10.1371/journal.pgen.1009618.s006
DOI:
10.1371/journal.pgen.1009618.s007
DOI:
10.1371/journal.pgen.1009618.s008
DOI:
10.1371/journal.pgen.1009618.s009
DOI:
10.1371/journal.pgen.1009618.s010
DOI:
10.1371/journal.pgen.1009618.r001
DOI:
10.1371/journal.pgen.1009618.r002
DOI:
10.1371/journal.pgen.1009618.r003
DOI:
10.1371/journal.pgen.1009618.r004
DOI:
10.1371/journal.pgen.1009618.r005
DOI:
10.1371/journal.pgen.1009618.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
Bookmarklink