In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 4666-4666
Abstract:
Rationale: Previously, we reported that common variants in pre-miRNA sequences played a role in the prediction of non-small-cell lung cancer (NSCLC) survival. Objectives: To assess whether variants in the pre-miRNA flanking region can influence the clinical behavior of NSCLC. Methods: we conducted a two-stage study to examine the impact of a panel of 85 SNPs on the overall survival of 923 NSCLC patients (568 in the screening set and 355 in the validation set) in China. Measurements and Main Results: Eleven single nucleotide polymorphisms (SNPs) were primarily associated with the NSCLC survival in the univariate analysis. However, in the validation set, only miR-30c-1 rs928508 was consistently a NSCLC survival predictor and the protective role of rs928508 AG/GG genotypes were more pronounced among early stage (stage I/II) patients and patients treated with surgery. The area under curve (AUC) at year 5 was significantly increased from 0.658 to 0.741 after adding the miR-30c-1 rs928508 risk score to the traditional clinical risk score (stage and surgery). Furthermore, in the genotype-phenotype correlation analysis, rs928508 AG/GG genotypes were associated with a significantly decreased expression of precursor and mature miR-30c (P=0.009 and 0.011), but not with that of its primary miRNA. The expression of the host nuclear transcription factor Y (NFYC) gene was correlated with pri-mir-30c-1, but not with rs928508 genotypes, implicating the co-regulation of the transcription of NFYC and pri-mir-30c-1. Conclusions: Our data indicated, for the first time, that genetic polymorphisms in the pre-miRNA flanking region may be prognostic biomarkers of NSCLC, and rs928508 is such a potential candidate. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4666. doi:10.1158/1538-7445.AM2011-4666
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2011-4666
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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