In:
BMC Ophthalmology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
Abstract:
Branch retinal vein occlusion (BRVO) is one of the most important causes of visual loss in retinal vascular diseases. The aim of this study is to predict the treatment response of anti-vascular endothelial growth factor (anti-VEGF) therapy in BRVO using semi-automated quantified fluorescein angiography (FA) features. Methods This retrospective case-control study enrolled patients with BRVO who are receiving anti-VEGF therapy and have been followed up for 〉 1 year. Those receiving 〈 5 anti-VEGF injections in the first year were classified as the responsive group, while those receiving ≥5 injections were the refractory group. The FA images were subjected to semi-automated pre-processing. Fluorescein leakages at the 5-min image were represented by mean gray value over parafoveal and perifoveal regions. FA leakages and central retinal thickness (CRT) on optical coherence tomography (OCT) were used for predicting the treatment response and compared using area under receiver operating characteristic curve (AUC). Results Eighty-nine patients (56 males, 33 females, mean age 62.5 ± 10.9 years) with BRVO were enrolled. Of the 89 eyes, 47 (53%) were in the responsive group and 42 (47%) were in the refractory group. The refractory group had a significantly higher number of anti-VEGF injections in the first year (5.9 ± 1.6 versus 2.4 ± 1.2, p 〈 0.001) when compared with that of the responsive group. It had thicker pre-treatment CRT ( p = 0.011), post-treatment best CRT ( p 〈 0.001) and CRT at 1-year ( p 〈 0.001). It also had a higher mean gray value over the parafoveal ( p 〈 0.001) and the perifoveal ( p 〈 0.001) regions. The mean gray value over perifoveal (AUC 0.846) and parafovel (AUC 0.818) had significantly larger AUC than that of the pre-treatment OCT (AUC 0.653; p = 0.005 and p = 0.016, respectively) when predicting treatment response. Conclusion The refractory group had a more severe fluorescein leakage over the parafoveal and the perifoveal regions than the responsive group had. Semi-automated quantified FA leakage can be used as a biomarker for the prediction of anti-VEGF treatment response in macular edema due to BRVO.
Type of Medium:
Online Resource
ISSN:
1471-2415
DOI:
10.1186/s12886-022-02245-w
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2050436-6
Bookmarklink