In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 15, No. 3 ( 2000-03-10), p. 284-289
Abstract:
Background : Non‐ulcer dyspepsia (NUD) accounts for the majority of dyspeptic patients and studies on the epidemiology of Helicobacter pylori infection in NUD depend on a non‐invasive and rapid diagnostic test. This study was performed to determine the sensitivity and specificity of a 15‐min simplified protocol of the [ 13 C]‐urea breath test ([ 13 C]‐UBT) for the diagnosis of H. pylori infection in patients with NUD. Methods : One hundred and thirty‐six patients with a clinical and endoscopic diagnosis of NUD were included. The [ 13 C]‐UBT was modified from the European standard protocol. The baseline breath sample was collected 5 min after the patient took a test meal and the 13 CO 2 was collected 15 min after the patient drank 100 mg [ 13 C]‐urea. The gold standard used for comparison was either a positive culture or positive histology + positive rapid urease test sampled on upper gastrointestinal endoscopy. Results : The prevalence of H. pylori infection in NUD by the gold standard was 59.6%, whereas that calculated by the [ 13 C]‐UBT was 60.3%. The sensitivity and specificity of [ 13 C]‐UBT was 93.8 and 89.1% compared with the gold standard. The shortened collection time and simplification of the procedure may have led to a decline in specificity. Conclusion : The 15‐min [ 13 C]‐UBT is a rapid but less specific protocol for detecting the presence of H . pylori infection in patients with NUD. © 2000 Blackwell Science Asia Pty Ltd
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1046/j.1440-1746.2000.02159.x
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
2006782-3
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