In:
Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 21, No. 1 ( 2020-01-07), p. 79-88
Abstract:
Large-scale population studies showed that the SNP rs1764391 of Connexin37
gene also known as Cx37 gene may play a pivotal role in the occurrence and development of acute myocardial infarction (AMI). Published results, however, are highly controversial. Objective: This study aimed to examine the association between SNP rs1764391 of Cx37 and diseasesusceptibility,
several risk factors, and gene-environment interactions of AMI in Guangxi Han Chinese population. Methods: In this study, 344 healthy controls and 344 AMI patients of Han Chinese population were
enrolled. The TaqMan assay was implemented to identify genotypes of Cx37 and allele frequencies of SNP rs1764391 in both the AMI and control groups. Results: Significant differences were detected in TT genotype frequencies of SNP rs1764391 between
the AMI and control groups (P 〈 0.05). In the context of gender stratification, the result was also statistically
different in women (P 〈 0.05). Each variable such as age, BMI, diabetes, high blood pressure,
smoking and TC was a risk factor and correlated significantly (P 〈 0.05) with the development of
AMI. HDL-C correlated negatively with the risk of AMI (P 〈 0.001). BMI, smoking or alcohol consumed
interacts significantly (P 〈 0.017) with the presence of the SNP rs1764391 CC genotype. Conclusions: Evidences were presented that Cx37 rs1764391 variation may contribute to the risk for
AMI, especially in women and this genetic variant may prove to be a potential biomarker for AMI risk stratification and may prove to be a useful target for therapeutic intervention to further improve prognosis
in high-risk patients.
Type of Medium:
Online Resource
ISSN:
1389-2010
DOI:
10.2174/1389201019666191003150015
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2020
SSG:
15,3
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