In:
Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 41, No. 4 ( 2022), p. 433-440
Abstract:
Background: To investigate the effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of inflammatory factors such as Interleukin-6 (IL6), Interleukin-8 (IL-8), Tumor necrosis factor-a (TNF-a) and coagulation factors in peripheral blood of elderly patients after hip arthroplasty to provides reference value for the choice of intraoperative anesthesia. Methods: 96 elderly patients underwent hip arthroplasty in our hospital from March 2018 to December 2019 were selected and divided into ultrasound-guided lumbar-sciatic nerve block group (group A) and epidural anesthesia group (group B) randomly , there were 48 cases in each group. The onset time of intraoperative anesthesia, postoperative hemodynamic indexes, pain score, inflammatory factors and blood coagulation factor levels were compared between group A and group B. Results: It was proved that: (1) The onset time of sensory block and motor block in group B were shorter compared with group A, and the maintenance time of anesthesia was prolonged (P 〈 0.05); (2) Compared with group A, visual analogue scale (VAS) score of group B patients after operation was lower (P 〈 0.05); (3) The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of group B were higher than group A (P 〈 0.05) ) at T1 and T2, while the comparison of SBP and DBP between groups was not statistical difference at T3 and T4 (P 〉 0.05); (3) Compared with group A, the levels of TNF, IL-8and IL-6 in peripheral blood of group B decreased after T2, T3 and T4 (P 〈 0.05); (4) Statistical difference in plasma factor V activity (FV:C), coagulation factor VIII activity (FVIII:C) and fibrinogen (FIB) levels were showed between groups A and B at T2, T3 and T4 (P 〈 0.05) with significantly lower values in group B compared to group A(P 〈 0.05). (5) The half-year mortality rates of patients in two group were 5.56% and 8.33% respectively. There was no significant difference between group A and group B (P 〉 0.05). Conclusions: Compared with epidural anesthesia, lumbarsciatic nerve block is showed significantly lower values in concentration of peripheral blood coagulation factors and inflammatory factors after surgery, thereby allevia
Type of Medium:
Online Resource
ISSN:
1452-8258
,
1452-8266
Uniform Title:
Efekti ultrazvučno vođene blokade lumbalno-šijadićnog nerva i epiduralne anestezije na nivoe IL-6, IL-8, TNF-a i faktora koagulacije u perifernoj krvi starijih pacijenata nakon artroplastike kuka
Language:
English
Publisher:
Centre for Evaluation in Education and Science (CEON/CEES)
Publication Date:
2022
detail.hit.zdb_id:
2405112-3
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