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Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal-Regulated Kinase Pathway

Hung, Chien-Hui ; Chen, Lee-Wen ; Wang, Wen-Hung ; [weitere]

American Society for Microbiology ; 2014

In: Journal of Virology Vol. 88, No. 20 ( 2014-10-15), p. 12133-12145

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In: Journal of Virology, American Society for Microbiology, Vol. 88, No. 20 ( 2014-10-15), p. 12133-12145

Kurzfassung: Autophagy is a cellular process that degrades and recycles nutrients under stress conditions to promote cell survival. Although autophagy commonly serves as a defense mechanism against viral infection, many viruses exploit this mechanism to promote their replication. This study finds that a transcription factor that is encoded by Epstein-Barr virus (EBV), Rta, activates autophagy, and the inhibition of autophagy reduces the ability of the virus to express viral lytic proteins and to generate progeny. Unlike other virus-encoded proteins that modulate autophagy by interacting with proteins that are involved in the autophagic pathway, Rta activates the transcription of the autophagy-related genes via the ERK pathway. The results of this study reveal how the virus manipulates autophagy to promote its lytic development.

Materialart: Online-Ressource

ISSN: 0022-538X , 1098-5514

URL: Article

DOI: 10.1128/JVI.02033-14

Sprache: Englisch

Verlag: American Society for Microbiology

Publikationsdatum: 2014

ZDB Id: 1495529-5

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Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2

Chen, Yeh ; Yang, Wen-Hao ; Chen, Hsiao-Fan ; [weitere]

Elsevier BV ; 2022

In: Journal of Biological Chemistry Vol. 298, No. 3 ( 2022-03), p. 101658-

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 298, No. 3 ( 2022-03), p. 101658-

Materialart: Online-Ressource

ISSN: 0021-9258

URL: Article

DOI: 10.1016/j.jbc.2022.101658

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2022

ZDB Id: 2141744-1

ZDB Id: 1474604-9

SSG: 12

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The C-Terminus of Histone H2B Is Involved in Chromatin Compaction Specifically at Telomeres, Independently of Its Monoubiquitylation at Lysine 123

Wang, Chen-Yi ; Hua, Chia-Yin ; Hsu, Hsiang-En ; [weitere]

Public Library of Science (PLoS) ; 2011

In: PLoS ONE Vol. 6, No. 7 ( 2011-7-29), p. e22209-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 6, No. 7 ( 2011-7-29), p. e22209-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0022209

DOI: 10.1371/journal.pone.0022209.g001

DOI: 10.1371/journal.pone.0022209.g002

DOI: 10.1371/journal.pone.0022209.g003

DOI: 10.1371/journal.pone.0022209.g004

DOI: 10.1371/journal.pone.0022209.g005

DOI: 10.1371/journal.pone.0022209.g006

DOI: 10.1371/journal.pone.0022209.g007

DOI: 10.1371/journal.pone.0022209.s001

DOI: 10.1371/journal.pone.0022209.s002

DOI: 10.1371/journal.pone.0022209.s003

DOI: 10.1371/journal.pone.0022209.s004

DOI: 10.1371/journal.pone.0022209.s005

DOI: 10.1371/journal.pone.0022209.s006

DOI: 10.1371/journal.pone.0022209.s007

DOI: 10.1371/journal.pone.0022209.s008

DOI: 10.1371/journal.pone.0022209.s009

DOI: 10.1371/journal.pone.0022209.s010

DOI: 10.1371/journal.pone.0022209.s011

DOI: 10.1371/journal.pone.0022209.s012

DOI: 10.1371/journal.pone.0022209.s013

DOI: 10.1371/journal.pone.0022209.s014

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2011

ZDB Id: 2267670-3

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Incidences, risk factors, and clinical correlates of severe QT prolongation after the use of quetiapine or haloperidol

Wang, Chun-Li ; Wu, Victor Chien-Chia ; Lee, Cheng Hung ; [weitere]

Elsevier BV ; 2024

In: Heart Rhythm ( 2024-1)

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In: Heart Rhythm, Elsevier BV, ( 2024-1)

Materialart: Online-Ressource

ISSN: 1547-5271

URL: Article

DOI: 10.1016/j.hrthm.2023.10.027

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2024

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A new sterol from the Formosan soft coral Lobophytum durum

Hung, Chia-Ling ; Huang, Li-Chieh ; Shih, Kun-Yauh ; [weitere]

Elsevier BV ; 2024

In: Journal of Molecular Structure Vol. 1296 ( 2024-01), p. 136790-

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In: Journal of Molecular Structure, Elsevier BV, Vol. 1296 ( 2024-01), p. 136790-

Materialart: Online-Ressource

ISSN: 0022-2860

URL: Article

DOI: 10.1016/j.molstruc.2023.136790

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2024

ZDB Id: 1491504-2

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Effectiveness of a Problem-Solving Program in Improving Problem-Solving Ability and Glycemic Control for Diabetics with Hypoglycemia

Wu, Fei-Ling ; Lin, Chia-Hung ; Lin, Chia-Ling ; [weitere]

MDPI AG ; 2021

In: International Journal of Environmental Research and Public Health Vol. 18, No. 18 ( 2021-09-10), p. 9559-

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In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 18 ( 2021-09-10), p. 9559-

Kurzfassung: The purpose of this study was to evaluate the effects of a hypoglycemia problem-solving program (HPSP) on problem-solving ability and glycemic control in diabetics with hypoglycemia. This was a prospective, quasi-experimental study with two groups, using a pre- and post-repeated measures design. A total of 71 diabetic patients with hypoglycemia were purposively assigned to an experimental group (n = 34) and a control group (n = 37). The experimental group participated in an 8-week HPSP, and each weekly session lasted approximately 90 min, while the control group received usual care. Participants were assessed at baseline, 1, 3, and 6 months after intervention care. In the experimental group, 6 months after the HPSP intervention, HbA1c was superior to that before the intervention. In both groups, the score obtained using the hypoglycemia problem-solving scale (HPSS) was low before the intervention. In the experimental group, HPSS tracking improved at all stages after the intervention compared to before the intervention. In the control group, the HPSS score improved slightly in the first month and sixth months after usual care. There were significant differences between and within groups in HbA1c levels and HPSS score over time. The intervention based on the HPSP effectively improves HbA1c level and hypoglycemia problem-solving ability in patients with hypoglycemia.

Materialart: Online-Ressource

ISSN: 1660-4601

URL: Article

DOI: 10.3390/ijerph18189559

Sprache: Englisch

Verlag: MDPI AG

Publikationsdatum: 2021

ZDB Id: 2175195-X

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Using immersive situation to confirm cleaner's education effectiveness in regional teaching hospital

Yu, Shao-Hua ; Yang, Shu-Ling ; Chen, Li-Nu ; [weitere]

Elsevier BV ; 2015

In: Journal of Microbiology, Immunology and Infection Vol. 48, No. 2 ( 2015-04), p. S98-S99

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In: Journal of Microbiology, Immunology and Infection, Elsevier BV, Vol. 48, No. 2 ( 2015-04), p. S98-S99

Materialart: Online-Ressource

ISSN: 1684-1182

URL: Article

DOI: 10.1016/j.jmii.2015.02.349

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2015

ZDB Id: 2175858-X

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The effect of patient volume on mortality and morbidity of extremely low birth weight infants in Taiwan

Wu, Chia-Ling ; Chen, Chia-Huei ; Chang, Jui-Hsing ; [weitere]

Elsevier BV ; 2023

In: Journal of the Formosan Medical Association ( 2023-6)

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In: Journal of the Formosan Medical Association, Elsevier BV, ( 2023-6)

Materialart: Online-Ressource

ISSN: 0929-6646

URL: Article

DOI: 10.1016/j.jfma.2023.05.024

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2023

ZDB Id: 2250901-X

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Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients

Yen, Ling-Jung ; Yen, Chung-Yang ; Li, Chia-Ling ; [weitere]

MDPI AG ; 2022

In: Journal of Personalized Medicine Vol. 12, No. 11 ( 2022-11-10), p. 1888-

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In: Journal of Personalized Medicine, MDPI AG, Vol. 12, No. 11 ( 2022-11-10), p. 1888-

Kurzfassung: Psoriasis is a predominantly Th17 cell-driven chronic autoinflammatory skin disorder. Brevilin A, a natural sesquiterpene lactone extracted from Centipeda minima, has been used as a traditional oriental medicine for allergic diseases for centuries. However, the effects of brevilin A on psoriasis have yet to be established. In this study, we investigated brevilin A to elucidate its potential effects on T cell activities in psoriasis, in animal models and patients. An imiquimod (IMQ)-induced psoriasis-like dermatitis murine model was utilized. Experimental mice were administered different doses of brevilin A (5, 10, 20 mg/kg respectively) for a duration of 5 days. Cutaneous manifestations were measured daily. Under hematoxylin and eosin (H & E) stain and immunohistochemistry (IHC), acanthosis and proinflammatory cytokine expression in the dorsal skin of mice were detected. Enzyme-linked immunosorbent assay (ELISA) was used for the measurement of IL-17A levels in serum samples. Naïve CD4+ T cells, isolated from mice spleen and lymph nodes and from peripheral blood mononuclear cells (PBMCs) of psoriatic patients, were used to evaluate the effects of brevilin A on Th17 differentiation. In brevilin A-treated mice, brevilin A significantly reduced skin redness and scaling; acanthosis as well as IL-6, IL-17A, and ki-67 expressions were downregulated in the dorsal skin, and serum levels of IL-17A were lowered. Brevilin A also inhibited Th17 differentiation. In conclusion, brevilin A demonstrated significant capability in ameliorating skin inflammation in IMQ-induced psoriasis-like dermatitis and could modulate Th17 differentiation. Therefore, brevilin A is potentially pharmacologically effective in the treatment of psoriasis.

Materialart: Online-Ressource

ISSN: 2075-4426

URL: Article

DOI: 10.3390/jpm12111888

Sprache: Englisch

Verlag: MDPI AG

Publikationsdatum: 2022

ZDB Id: 2662248-8

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Forsythoside A Alleviates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Regulating Th17 Cells and IL-17A Expression

Lin, Hsuan ; Li, Chia-Ling ; Yen, Ling-Jung ; [weitere]

MDPI AG ; 2022

In: Journal of Personalized Medicine Vol. 12, No. 1 ( 2022-01-06), p. 62-

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In: Journal of Personalized Medicine, MDPI AG, Vol. 12, No. 1 ( 2022-01-06), p. 62-

Kurzfassung: Psoriasis is a recurrent inflammatory skin disease characterized by redness and scaly skin lesions with itchy or painful sensations. Forsythoside A, one of the main active compounds isolated from the fruit of Forsythia suspensa, has been widely applied to treat inflammatory diseases in the clinical use of traditional oriental medicine. However, the effect of forsythoside A on psoriasis remains unclear. This study aimed to explore the therapeutic effects and immune regulation of forsythoside A on psoriasis. C57BL/6 mice were divided into six groups and treated with imiquimod cream on their shaved back skin to induce psoriasis-like dermatitis. Different doses of forsythoside A (5 mg/kg, 10 mg/kg, or 20 mg/kg) were administered to the respective treatment groups. Skin redness, scaling, and ear thickness were measured; keratinocyte proliferation and inflammatory cytokine expression were detected by hematoxylin–eosin and immunohistochemical staining. Th17 cells in the inguinal lymph nodes were detected by flow cytometric analysis. IL-17A levels were measured using ELISA. The results showed that forsythoside A relieved psoriatic skin symptoms such as skin redness, thickness, scaling, and reduced epidermal thickening. The expression of IL-6, IL-17, and Ki-67 was downregulated in the forsythoside-A-treated groups. Th17 cell expression in inguinal lymph nodes and IL-17A secretion was suppressed by forsythoside A. In conclusion, forsythoside A was found to alleviate imiquimod-induced psoriasis-like dermatitis in mice by suppressing Th17 development and IL-17A secretion. These findings demonstrate the feasibility of forsythoside A in treating human psoriasis.

Materialart: Online-Ressource

ISSN: 2075-4426

URL: Article

DOI: 10.3390/jpm12010062

Sprache: Englisch

Verlag: MDPI AG

Publikationsdatum: 2022

ZDB Id: 2662248-8

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