In:
FEBS Letters, Wiley, Vol. 299, No. 1 ( 1992-03-02), p. 48-50
Abstract:
Poliovirus, a picornavirus family member, requires the processing of its poly‐protein by its own cysteine proteinase for replication. Oryzacystatin‐I and oryzacystatin‐II, proteinaceous cysteine proteinase inhibitors (cystatins) of rice seed origin, were found to inhibit the replication of poliovirus effectively in infected Vero cells in vitro. Truncated oryzacystatin‐I, which lacks the NH 2 ‐terminal 25 amino acid residues of the intact protein, is an even more effective inhibitor, eliciting its effect at concentrations of less than 0.23 nmol/ml. The low molecular weight cysteine proteinase inhibitors, E‐64, E‐64C and loxistatin, showed no anti‐viral effect at any concentration investigated.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(92)80097-Z
Language:
English
Publisher:
Wiley
Publication Date:
1992
detail.hit.zdb_id:
1460391-3
SSG:
12
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