In:
FEBS Letters, Wiley, Vol. 323, No. 1-2 ( 1993-05-24), p. 23-26
Abstract:
Contribution of phosphatidic acid (PA) generated by activated phospholipase (PL) D to PLA 2 activation was studied in rat peritoneal mast cells. Exogenous didecanoyl PA induced arachidonate liberation in the permeabilized cells which was inhibited by p ‐bromophenacyl bromide. Upon exposure of the cells to ethanol in a high enough concentration to prevent PA formation, A23187‐induced arachidonate liberation was suppressed by 50% and the rest was completely inhibited by p ‐bromophenacyl bromide. In contrast, propranolol, which enhanced PA accumulation, significantly increased the arachidonate liberation. These results suggest that A23187‐induced PLA 2 activation may be potentiated, at least in part, by PA generated through PLD action.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(93)81440-B
Language:
English
Publisher:
Wiley
Publication Date:
1993
detail.hit.zdb_id:
1460391-3
SSG:
12
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