In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 133, No. 1 ( 1995-07), p. 121-126
Abstract:
Oda N, Nakai A, Mokuno T, Sawai Y, Nishida Y, Mano T, Asano K, Itoh Y, Kotake M, Kato S, Masunaga R, Iwase K, Tsujimura T, Itoh M, Kawabe T, Nagasaka A. Dexamethasone-induced changes in glucose transporter 4 in rat heart muscle, skeletal muscle and adipocytes. Eur J Endocrinol 1995;133:121–6. ISSN 0804–4643 To clarify the effect of glucocorticoid on glucose transporters (GLUT) in adipocytes and muscle, we examined the changes of GLUT4 in rat heart muscle, skeletal muscle and adipocytes during long-term administration of dexamethasone and the translocation of GLUT4. The levels of GLUT4 in the plasma membrane and the low-density microsome fraction were measured by Western blotting using anti-GLUT4 peptide antibody. The levels of GLUT4 in the heart and skeletal muscles of rat were unchanged by treatment of dexamethasone. In the adipocytes the level of GLUT4 in plasma membrane was changed, but it was decreased in the low-density microsome fraction. Although adipocytes are less involved in blood sugar regulation than skeletal muscle, this finding suggests that glucose metabolism in Cushing's syndrome is affected partly by a decrease of GLUT4 in the adipocytes. Akio Nagasaka, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi 470-11, Japan
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/eje.0.1330121
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1995
detail.hit.zdb_id:
1485160-X
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