In:
American Journal of Nephrology, S. Karger AG, Vol. 26, No. 1 ( 2006), p. 12-15
Abstract:
〈 i 〉 Background: 〈 /i 〉 Tumor necrosis factor-α (TNF-α) is a major pro-inflammatory cytokine. Recently, the G-308A polymorphism of the TNF-α gene has been associated with modified gene expression and increased TNF-α production in the -308A allele. We evaluated its influence on the incidence and clinical course of membranous glomerulonephritis. 〈 i 〉 Methods: 〈 /i 〉 We studied 53 patients with biopsy-proven primary membranous glomerulonephritis followed up for 5.7 ± 4.9 years. 100 volunteers were analyzed as controls. According to the slope of the curve of reciprocal serum creatinine against time, group A (slow progressors, n = 35) and group B (fast progressors, n = 18) were defined. TNF-α G-308A polymorphism was determined by polymerase chain reaction amplification. 〈 i 〉 Results: 〈 /i 〉 The frequency of the A-allele (associated with higher TNF-α levels) was significantly higher in patients than control subjects (patients: G-allele: 0.66, A-allele: 0.34; controls: G-allele 0.85, A-allele 0.15, p 〈 0.001). Similarly, the genotype distribution differed significantly between our study and control populations (patients: GG-genotype: 41.5%, GA: 49.1%, AA 9.4%; controls: GG: 71%, GA: 27%, AA 2%, p = 0.001). Age, renal function, proteinuria and blood pressure were similar at the time of renal biopsy between patients with different genotypes (NS). There was also a tendency towards an overpresentation of the A-allele in group B indicating a possible impact on the progression of membranous nephropathy, but a significance was not reached. Furthermore, no impact on renal survival in the Kaplan- Meier analysis was detected (NS). 〈 i 〉 Conclusion: 〈 /i 〉 Our results suggest that TNF-α gene G-308A polymorphism is a risk factor for the development of membranous glomerulonephritis.
Type of Medium:
Online Resource
ISSN:
0250-8095
,
1421-9670
Language:
English
Publisher:
S. Karger AG
Publication Date:
2006
detail.hit.zdb_id:
1468523-1
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