In:
International Wound Journal, Wiley, Vol. 13, No. 5 ( 2016-10), p. 799-808
Abstract:
The aim of this study was to investigate the wound‐healing activity of (–)‐borneol ( BOR ) incorporated in chitosan film on healing protocol in rodents. To assess the BOR wound‐healing potential, male Wistar rats were subjected to a full‐thickness excisional wound. The animals were divided into three groups: dressed with chitosan‐based film ( QUIN ); dressed with chitosan‐based film containing 0·5% BOR ( QUIBO05 ); or dressed with chitosan‐based film containing 1% BOR ( QUIBO1 ). Dressing the wound areas and histological analysis were performed on the 3rd, 7th, 14th, and 21st days. The myeloperoxidase ( MPO ) activity was assessed on the third and seventh days after surgical procedures. Wounds dressed with chitosan‐based film containing BOR reduced significantly the MPO activity ( P 〈 0·001), showed significantly larger wound retraction rates (7 days, P 〈 0·05), improved the granulation reaction, and also provided better collagenisation density and arrangement during wound healing. It is suggested that BOR modulates the wound‐healing process and is a promising compound to be used in wound care. This product may be quite useful in improving wound healing and could be a new biotechnological product with healing properties and clinical application. Further ongoing studies will enable us to understand the precise mechanisms whereby BOR improves the wound‐healing process.
Type of Medium:
Online Resource
ISSN:
1742-4801
,
1742-481X
DOI:
10.1111/iwj.2016.13.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2152163-3
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