In:
Chemistry & Biodiversity, Wiley, Vol. 16, No. 11 ( 2019-11)
Abstract:
The antibacterial and antibiofilm activities of two new ruthenium complexes against E. coli , S. aureus , P. aeruginosa PAO1 (laboratory strain) and P. aeruginosa LES B58 (clinical strain) were evaluated. Complexes, mer ‐[Ru III (2‐bimc) 3 ] ⋅ H 2 O ( 1 ) and cis ‐[Ru IV Cl 2 (2,3‐pydcH) 2 ] ⋅ 4H 2 O ( 2 ), were obtained using aromatic carboxylic acid ligands, namely, 1 H ‐benzimidazole‐2‐carboxylic acid (2‐bimcH) and pyridine‐2,3‐dicarboxylic acid (2,3‐pydcH 2 ). Compounds were physicochemically characterized using X‐ray diffraction, Hirshfeld surface analysis, IR and UV/VIS spectroscopies, as well as magnetic and electrochemical measurements. Structural characterization revealed that Ru(III) and Ru(IV) ions in the complexes adopt a distorted octahedral geometry. The intermolecular classical and weak hydrogen bonds, and π ⋅⋅⋅ π contacts significantly contribute to structure stabilization, leading to the formation of a supramolecular assembly. Biological studies have shown that the Ru complexes inhibit the growth of bacteria and biofilm formation by the tested strains and the complexes seem to be a potential as antimicrobial agents.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201900403
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2139001-0
SSG:
12
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