In:
Blood Purification, S. Karger AG, Vol. 31, No. 1-3 ( 2011), p. 9-17
Abstract:
〈 i 〉 Background: 〈 /i 〉 C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction. 〈 i 〉 Methods: 〈 /i 〉 We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction. 〈 i 〉 Results: 〈 /i 〉 We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ∼70% in the established treatment system. 〈 i 〉 Conclusion: 〈 /i 〉 We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14.
Type of Medium:
Online Resource
ISSN:
0253-5068
,
1421-9735
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1482025-0
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