In:
APMIS, Wiley, Vol. 126, No. 3 ( 2018-03), p. 234-240
Abstract:
Polychlorinated biphenyls ( PCB s), and similar environmental contaminants, have been linked to virus outbreaks and increased viral induced mortality since the 1970s. Yet the mechanisms behind this increased susceptibility remain elusive. It has recently been illustrated that the innate immune viral detection system is tightly regulated by small non‐coding RNA s, including micro RNA s (mi RNA s). For virus infections mi RNA ‐155 expression is an important host response against infection, and deregulation of this mi RNA is closely associated with adverse outcomes. Thus, we designed a targeted in vitro study using primary chicken fibroblasts, first exposed to a mixture of PCB s (Arochlor‐1250) before being stimulated with a synthetic RNA virus (poly I:C), to determine if PCB s have the potential to deregulate mi RNA ‐155. In this paper, we provide the first data for the deregulation of mi RNA ‐155 when a host is exposed to a mixture of PCB s before a virus infection. Thus, we provide important evidence that PCB s can be involved in the deregulation of important mi RNA pathways involved in the immune system; thereby demonstrating novel insights into the mechanism of PCB toxicity on the immune system.
Type of Medium:
Online Resource
ISSN:
0903-4641
,
1600-0463
DOI:
10.1111/apm.2018.126.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2098213-6
SSG:
12
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