In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-06-19)
Abstract:
Thymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein ( 1 ), a major component of Scutellaria baicalensis , was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a , a biphenyl flavanone analog, as a novel human TSLP inhibitor for the discovery and development of new anti-allergic drugs.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-019-44853-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2019
detail.hit.zdb_id:
2615211-3
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