In:
Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 38, No. 2 ( 2019-03-03), p. 126-133
Abstract:
We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p 〈 0.001; B: p 〈 0.001, C: p 〈 0.05; D: p 〈 0.001 mg/L), (A: p 〈 0.001 B: p 〈 0.001, C: p 〈 0.001, D: p 〈 0.01 pg/mL), (A: p 〈 0.001, B: p 〈 0.001; C: p 〈 0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p 〈 0.001, p 〈 0.01), IL-6 lower (p 〈 0.05, p 〈 0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP
Type of Medium:
Online Resource
ISSN:
1452-8266
DOI:
10.2478/jomb-2018-0024
Language:
Unknown
Publisher:
Centre for Evaluation in Education and Science (CEON/CEES)
Publication Date:
2019
detail.hit.zdb_id:
2405112-3
Bookmarklink