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Detecting Adverse Pathology of Prostate Cancer With a Deep Learning Approach Based on a 3D Swin‐Transformer Model and Biparametric MRI : A Multicenter Retrospective Study

Zhao, Litao ; Bao, Jie ; Wang, Ximing ; [et al.]

Wiley ; 2023

In: Journal of Magnetic Resonance Imaging

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In: Journal of Magnetic Resonance Imaging, Wiley

Abstract: Accurately detecting adverse pathology (AP) presence in prostate cancer patients is important for personalized clinical decision‐making. Radiologists' assessment based on clinical characteristics showed poor performance for detecting AP presence. Purpose To develop deep learning models for detecting AP presence, and to compare the performance of these models with those of a clinical model (CM) and radiologists' interpretation (RI). Study Type Retrospective. Population Totally, 616 men from six institutions who underwent radical prostatectomy, were divided into a training cohort (508 patients from five institutions) and an external validation cohort (108 patients from one institution). Field Strength/Sequences T2‐weighted imaging with a turbo spin echo sequence and diffusion‐weighted imaging with a single‐shot echo plane‐imaging sequence at 3.0 T. Assessment The reference standard for AP was histopathological extracapsular extension, seminal vesicle invasion, or positive surgical margins. A deep learning model based on the Swin‐Transformer network (TransNet) was developed for detecting AP. An integrated model was also developed, which combined TransNet signature with clinical characteristics (TransCL). The clinical characteristics included biopsy Gleason grade group, Prostate Imaging Reporting and Data System scores, prostate‐specific antigen, ADC value, and the lesion maximum cross‐sectional diameter. Statistical Tests Model and radiologists' performance were assessed using area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. The Delong test was used to evaluate difference in AUC. P 〈 0.05 was considered significant. Results The AUC of TransCL for detecting AP presence was 0.813 (95% CI, 0.726–0.882), which was higher than that of TransNet (0.791 [95% CI, 0.702–0.863], P = 0.429), and significantly higher than those of CM (0.749 [95% CI, 0.656–0.827]) and RI (0.664 [95% CI, 0.566–0.752] ). Data Conclusion TransNet and TransCL have potential to aid in detecting the presence of AP and some single adverse pathologic features. Level of Evidence 4 Technical Efficacy Stage 4

Type of Medium: Online Resource

ISSN: 1053-1807 , 1522-2586

URL: Article

DOI: 10.1002/jmri.28963

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 1497154-9

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Hu'po Anshen decoction promotes fracture healing in mice with traumatic brain injury through BMP2‐COX2‐ATF4 signaling pathway

Ding, WeiHang ; Ji, RuiQing ; Yao, Sai ; [et al.]

Wiley ; 2023

In: The FASEB Journal Vol. 37, No. 6 ( 2023-06)

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In: The FASEB Journal, Wiley, Vol. 37, No. 6 ( 2023-06)

Abstract: Hu'po Anshen decoction (HPASD), a traditional Chinese medicine used to treat concussion and fracture, could regulate the expression of bone morphogenetic protein 2 (BMP2). However, whether HPASD affects the fracture healing of traumatic brain injury (TBI) combined with a fracture through BMP2 and its downstream signals remains obscure. The chondrocyte‐specific BMP2 conditional knockout mice and chondrocyte‐specific cyclooxygenase‐2 (COX2) overexpression mice were generated. BMP2 conditional knockout mice were treated with fracture surgery, fracture combined with TBI, or fracture combined with TBI followed by different doses of HPASD (2.4, 4.8, and 9.6 g/kg), respectively. TBI was induced by Feeney's weight‐drop technique. The fracture callus formation and fracture sites were determined by X‐ray, micro‐CT, and histological analyses. The expressions of chondrocyte‐, osteoblast‐, and BMP2/COX2 signal‐related targets were determined by quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) and western blot assays. The specific absence of BMP2 in chondrocytes led to the prolonged formation of cartilage callus, a delay in the osteogenesis initiation and the downregulation of RUNX2, Smad1/5/9, EP4, ERK1/2, RSK2, ATF4. Overexpression of COX2 partially reverses the effects of chondrocyte‐specific BMP2 knockout mice. HPASD promoted cartilage callus formation and osteogenesis initiation, as accompanied by upregulated expression levels of RUNX2, Smad1/5/9, EP4, ERK1/2, RSK2, and ATF4 in a time‐dependent and concentration‐dependent manner in chondrocyte‐specific BMP2 knockout mice. Overall, our findings demonstrated that HPASD induced COX2 transcription through the BMP2‐Smad1/5/9‐RUNX2 axis, and then affected fracture healing through the COX2‐mediated EP4‐ERK1/2‐RSK2‐ATF4 axis.

Type of Medium: Online Resource

ISSN: 0892-6638 , 1530-6860

URL: Issue

URL: Article

DOI: 10.1096/fsb2.v37.6

DOI: 10.1096/fj.202201552RR

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 1468876-1

SSG: 12

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Association between P2Y12 inhibitor reloading and in-hospital outcomes for patients with non-ST-segment elevation acute coronary syndrome already on chronic P2Y12 receptor inhibitors therapy in China: findings from the CCC–ACS (improving care for cardiovascular disease in China-acute coronary syndrome) project

Wang, Yintang ; Geng, Yu ; Zhang, Ou ; [et al.]

Springer Science and Business Media LLC ; 2023

In: European Journal of Medical Research Vol. 28, No. 1 ( 2023-02-02)

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In: European Journal of Medical Research, Springer Science and Business Media LLC, Vol. 28, No. 1 ( 2023-02-02)

Abstract: The association between P2Y12 receptor inhibitors reloading and in-hospital outcomes in non-ST-segment elevation acute coronary syndrome (NSTEACS) patients who were on chronic P2Y12 receptor inhibitors therapy remained underdetermined. Methods The Improving Care for Cardiovascular Disease in China–Acute Coronary Syndrome (CCC–ACS project) is a national registry active from November 2014 to December 2019. 4790 NSTEACS patients on chronic P2Y12 receptor inhibitors therapy were included. Cox proportional hazard models, Kaplan–Meier curves, and subgroup analyses were conducted. Results The NSTEACS patients who received reloading of P2Y12 receptor inhibitors were younger and had fewer comorbid conditions. The reloading group had a lower risk of major adverse cardiac events (MACE) (0.51% vs. 1.43%, P = 0.007), and all-cause death (0.36% vs. 0.99%, P = 0.028), the risks of myocardial infarction and major bleeding were not significantly different between patients with and without reloading. In survival analysis, a lower cumulative risk of MACE could be identified (Log-rank test, P = 0.007) in reloading group. In the unadjusted Cox model, reloading P2Y12 receptor inhibitors was associated with a decreased risk of MACE [HR, 0.35; 95% CI 0.16–0.78; ( P = 0.010)] and all-cause death [HR, 0.37; 95% CI 0.14–0.94; ( P = 0.036)]. Reloading of P2Y12 receptor inhibitors was associated with a decreased risk of MACE in most of the subgroups. Conclusions In NSTEACS patients already taking P2Y12 receptor inhibitors, we observed a decreased risk of in-hospital MACEs and all-cause mortality and did not observe an increased risk of major bleeding, with reloading. The differential profile in the two groups might influence this association and further studies are warranted. Clinical trial registration : https://www.clinicaltrials.gov (Unique identifier: NCT02306616, date of first registration: 03/12/2014)

Type of Medium: Online Resource

ISSN: 2047-783X

URL: Article

DOI: 10.1186/s40001-023-01025-6

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2129989-4

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Association Between Platelet Glycoprotein IIb/IIIa Inhibition and In-Hospital Outcomes in ST-Elevation Myocardial Infarction Patients Treated with Coronary Thrombus Aspiration: Findings from the CCC-ACS Project

Liu, Wennan ; Li, Ziping ; Yang, Tianqi ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Cardiovascular Drugs and Therapy

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In: Cardiovascular Drugs and Therapy, Springer Science and Business Media LLC

Type of Medium: Online Resource

ISSN: 0920-3206 , 1573-7241

URL: Article

DOI: 10.1007/s10557-022-07398-w

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2003553-6

SSG: 15,3

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Performance of Management Strategies With Class I Recommendations Among Patients Hospitalized With ST-Segment Elevation Myocardial Infarction in China

Hao, Yongchen ; Zhao, Dong ; Liu, Jing ; [et al.]

American Medical Association (AMA) ; 2022

In: JAMA Cardiology Vol. 7, No. 5 ( 2022-05-01), p. 484-

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In: JAMA Cardiology, American Medical Association (AMA), Vol. 7, No. 5 ( 2022-05-01), p. 484-

Type of Medium: Online Resource

ISSN: 2380-6583

URL: Article

DOI: 10.1001/jamacardio.2022.0117

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2022

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Predicting clinically significant prostate cancer with a deep learning approach: a multicentre retrospective study

Zhao, Litao ; Bao, Jie ; Qiao, Xiaomeng ; [et al.]

Springer Science and Business Media LLC ; 2023

In: European Journal of Nuclear Medicine and Molecular Imaging Vol. 50, No. 3 ( 2023-02), p. 727-741

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In: European Journal of Nuclear Medicine and Molecular Imaging, Springer Science and Business Media LLC, Vol. 50, No. 3 ( 2023-02), p. 727-741

Abstract: This study aimed to develop deep learning (DL) models based on multicentre biparametric magnetic resonance imaging (bpMRI) for the diagnosis of clinically significant prostate cancer (csPCa) and compare the performance of these models with that of the Prostate Imaging and Reporting and Data System (PI-RADS) assessment by expert radiologists based on multiparametric MRI (mpMRI). Methods We included 1861 consecutive male patients who underwent radical prostatectomy or biopsy at seven hospitals with mpMRI. These patients were divided into the training (1216 patients in three hospitals) and external validation cohorts (645 patients in four hospitals). PI-RADS assessment was performed by expert radiologists. We developed DL models for the classification between benign and malignant lesions (DL-BM) and that between csPCa and non-csPCa (DL-CS). An integrated model combining PI-RADS and the DL-CS model, abbreviated as PIDL-CS, was developed. The performances of the DL models and PIDL-CS were compared with that of PI-RADS. Results In each external validation cohort, the area under the receiver operating characteristic curve (AUC) values of the DL-BM and DL-CS models were not significantly different from that of PI-RADS ( P 〉 0.05), whereas the AUC of PIDL-CS was superior to that of PI-RADS ( P 〈 0.05), except for one external validation cohort ( P 〉 0.05). The specificity of PIDL-CS for the detection of csPCa was much higher than that of PI-RADS ( P 〈 0.05). Conclusion Our proposed DL models can be a potential non-invasive auxiliary tool for predicting csPCa. Furthermore, PIDL-CS greatly increased the specificity of csPCa detection compared with PI-RADS assessment by expert radiologists, greatly reducing unnecessary biopsies and helping radiologists achieve a precise diagnosis of csPCa.

Type of Medium: Online Resource

ISSN: 1619-7070 , 1619-7089

URL: Article

DOI: 10.1007/s00259-022-06036-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2098375-X

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Wide field of view optical phased array with a high-directionality antenna

Wang, Zheng ; Yu, Lei ; Yang, Yibo ; [et al.]

Optica Publishing Group ; 2023

In: Optics Express Vol. 31, No. 13 ( 2023-06-19), p. 21192-

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In: Optics Express, Optica Publishing Group, Vol. 31, No. 13 ( 2023-06-19), p. 21192-

Abstract: Light detection and ranging (LiDAR) is a widely utilized technology for extracting information from the outside world in fields such as automotive, robotics, and aerospace. Optical phased array (OPA) is a promising solution for LiDAR technology, although its application is limited by loss and alias-free steering range. In this paper, we propose a dual-layer antenna that achieves a peak directionality of over 92%, thereby mitigating antenna loss and enhancing power efficiency. Based on this antenna, we design and fabricate a 256-channel non-uniform OPA that achieves 150° alias-free steering.

Type of Medium: Online Resource

ISSN: 1094-4087

URL: Article

DOI: 10.1364/OE.492317

Language: English

Publisher: Optica Publishing Group

Publication Date: 2023

detail.hit.zdb_id: 1491859-6

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Evaluation Method for the Bearing Capacity of Reinforced Concrete Beams Based on the Kaiser Effect

Xu, Yongfeng ; Wang, Hailong ; Li, Minfeng ; [et al.]

MDPI AG ; 2023

In: Buildings Vol. 13, No. 8 ( 2023-08-05), p. 2003-

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In: Buildings, MDPI AG, Vol. 13, No. 8 ( 2023-08-05), p. 2003-

Abstract: The Kaiser effect is an important phenomenon that occurs in acoustic emission. The estimation of reinforced concrete structures based on acoustic emission is receiving widespread attention. Cumulative acoustic emission parameters were used for the preliminary estimation of Kaiser points through the step loading experiments on four simply supported reinforced concrete beams under bending load. Taking this Kaiser point as the centre, an appropriate interval value was determined. After functional fitting of the “load-acoustic emission parameter” curve, the difference between the estimated value and the measured value was calculated. The Kaiser point was modified in accordance with the “load-difference” curve. The modified Kaiser point was used to calculate the Felicity ratio. The ratio of the maximum load to the ultimate bearing capacity of the beams was calculated. The curves of the ratio and the Felicity ratio were obtained. Fitting of the corresponding relational function was performed. Based on the relational function, the ultimate bearing capacity of the beams was estimated according to the mean of the experiment. The results showed that if there was a significant difference between the preliminarily estimated value and the measured value of the Kaiser point, modifications can be conducted to avoid any significant difference in the Kaiser point caused by human factors. Using the Felicity ratio and based on function fitting, the maximum difference in the ultimate bearing capacity of the beams was estimated to be no more than 10%. Moreover, it was concluded that the estimated ultimate bearing capacity of the beams was characterized by high stability in the case of different sample data. This method will provide a theoretical basis for evaluating the ultimate bearing capacity of reinforced concrete beams under bending load based on the Kaiser effect.

Type of Medium: Online Resource

ISSN: 2075-5309

URL: Article

DOI: 10.3390/buildings13082003

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 2661539-3

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High-directionality SiN-assisted grating antenna for optical phased array

Wang, Zheng ; Yang, Yibo ; Cui, Langlin ; [et al.]

Optica Publishing Group ; 2023

In: Journal of the Optical Society of America B Vol. 40, No. 8 ( 2023-08-01), p. 1994-

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In: Journal of the Optical Society of America B, Optica Publishing Group, Vol. 40, No. 8 ( 2023-08-01), p. 1994-

Abstract: In the realm of consumer electronics, automotive, and robotics, lidar has proven to be a valuable technology. However, current lidar solutions such as mechanical, microelectromechanical, and flash lidar are associated with drawbacks such as high cost, low resolution, and a limited ranging distance. To address these issues, optical phased array (OPA) technology has been proposed as a promising solution due to its high resolution, rapid response times, long ranging distance, and low cost. Despite these advantages, OPA is still in the developmental stages and further optimization is required to address issues such as loss, field of view (FOV), and beam divergence. To address the FOV and beam divergence issues, SiN-assisted grating antenna has been used. However, the directionality of an SiN-assisted antenna is relatively low and may introduce additional loss for OPA. To overcome this limitation, this paper proposes a dual-layer SiN-assisted grating antenna with more than 94% directionality in 1550 nm. Moreover, the wavelength bandwidth of more than 90% directionality is over 80 nm, making it a promising solution for OPA devices.

Type of Medium: Online Resource

ISSN: 0740-3224 , 1520-8540

URL: Article

DOI: 10.1364/JOSAB.493041

Language: English

Publisher: Optica Publishing Group

Publication Date: 2023

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Data_Sheet_3.docx

Zhang, Yongxin ; Liu, Pei ; Li, Zifu ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Neurology Vol. 13 ( 2022-12-14)

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In: Frontiers in Neurology, Frontiers Media SA, Vol. 13 ( 2022-12-14)

Abstract: The Neurohawk retriever is a new fully radiopaque retriever. A randomized controlled non-inferiority trial was conducted to compare the Neurohawk and the Solitaire FR in terms of safety and efficacy. In order to evaluate the efficacy and safety of endovascular treatment in acute ischemic stroke (AIS) caused by intracranial atherosclerotic disease (ICAD) larger vessel occlusion (LVO), a sub-analysis was performed. Methods Acute ischemic stroke patients aged 18–80 years with LVO in the anterior circulation were randomly assigned to undergo thrombectomy with either the Neurohawk or the Solitaire FR. The primary efficacy endpoint was successful reperfusion (mTICI 2b-3) rate by the allocated retriever. A relevant non-inferiority margin was 12.5%. Safety outcomes were symptomatic intracranial hemorrhage (sICH) and all-cause mortality within 90 days. Secondary endpoints included first-pass effect (FPE), modified FPE, and favorable outcomes at 90 days. In subgroup analysis, the patients were divided into the ICAD group and non-ICAD group according to etiology, and baseline characteristics, angiographic, and clinical outcomes were compared. Results A total of 232 patients were involved in this analysis (115 patients in the Neurohawk group and 117 in the Solitaire group). The rates of successful reperfusion with the allocated retriever were 88.70% in the Neurohawk group and 90.60% in the Solitaire group (95%CI of the difference, −9.74% to 5.94%; p = 0.867). There were similar results in FPE and mFPE in both groups. The rate of sICH seemed higher in the Solitaire group (13.16% vs. 7.02%, p = 0.124). All-cause mortality and favorable outcome rates were comparable as well. In subgroup analysis, 58 patients were assigned to the ICAD group and the remaining 174 to the non-ICAD group. The final successful reperfusion and favorable outcome rates showed no statistically significant differences in two groups. Mortality within 90 days was relatively lower in the ICAD group (6.90% vs. 17.24%; p = 0.054). Conclusion The Neurohawk retriever is non-inferior to the Solitaire FR in the mechanical thrombectomy of large vessel occlusion-acute ischemic stroke (LVO-AIS). The sub-analysis suggested that endovascular treatment including thrombectomy with the retriever and essential rescue angioplasty is effective and safe in AIS patients with intracranial atherosclerotic disease-larger vessel occlusion (ICAD-LVO). Clinical trial registration https://clinicaltrials.gov/ct2/show/NCT04995757 , number: NCT04995757.

Type of Medium: Online Resource

ISSN: 1664-2295

URL: Article

DOI: 10.3389/fneur.2022.962987

DOI: 10.3389/fneur.2022.962987.s001

DOI: 10.3389/fneur.2022.962987.s002

DOI: 10.3389/fneur.2022.962987.s003

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2564214-5

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