In:
Science Advances, American Association for the Advancement of Science (AAAS), Vol. 7, No. 5 ( 2021-01-29)
Abstract:
The efficacy of cancer immunotherapy is dictated by CD8 + T cell infiltration and the nature of the tumor microenvironment (TME). By inflaming the TME to favor CD8 + T cell immunity, radiation is now widely considered as a neoadjuvant for immunomodulation. Here, we observed that local irradiation enhances the infiltration of intratumoral eosinophils, and depletion of eosinophil dampens CD8 + T cell infiltration and diminishes the anti-tumor effectiveness of radiation. Retrospectively, we identified a strong correlation between eosinophilia and survival benefit in radiation-treated cancer patients. Experimentally, we further show that radiation enhances the intratumoral infiltration of adoptive transferred T cells therapy, bolstering eosinophils by intravenous interleukin-5 administration promotes the efficacy of radiation-induced abscopal effect. Together, these results suggest that eosinophil mobilization can be considered as a mechanistically relevant biomarker for predicting the effectiveness of pre-immunotherapy radiation, as well as a new strategy to enhance T cell-mediated immunotherapy against cancers.
Type of Medium:
Online Resource
ISSN:
2375-2548
DOI:
10.1126/sciadv.abc7609
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2021
detail.hit.zdb_id:
2810933-8
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