In:
Current Alzheimer Research, Bentham Science Publishers Ltd., Vol. 19, No. 9 ( 2022-08), p. 658-666
Abstract:
Recent findings suggest that both dietary protein intake and hand grip strength
(HGS) were associated with cognitive function, however, few studies have been devoted specifically to the mediation effect of HGS on the association of the dietary protein with cognitive function. Objectives: To confirm the hypothesis that HGS mediated the association of dietary protein intake with
cognitive function in the elderly, which was modified by triglyceride level and methylenetetrahydrofolate reductase (MTHFR) gene status. Methods: This cross-sectional study included 3,268 participants. Dietary protein intake, HGS, and
cognitive function were collected by food frequency questionnaires (FFQ), grip measurements and mini mental state examination (MMSE), respectively. In this mediation analysis, dietary protein intake
was entered as an independent variable, HGS was entered as a mediator, and cognitive function was entered as a dependent variable. Results: HGS significantly mediated the associations of dietary protein (β = 0.0013, 95% CI: 0.0007,
0.0022), animal protein (β = 0.0024, 95% CI: 0.0012, 0.0037), and plant protein intake (β = 0.0011, 95% CI: 0.0001, 0.0023) with cognitive function in total participants, with the mediated proportion of
16.19%, 12.45% and 20.57%, respectively. Furthermore, significant mediation effects of HGS on the associations of dietary protein, animal protein, and plant protein intake with MMSE score were found
in the elderly without hypertriglyceridemia or in MTHFR C677T CC/CT carriers. Conclusion: This study suggested that HGS mediated the association of dietary protein intake with
cognitive function, and this mediation effect was modified by triglyceride level and MTHFR C677T gene status.
Type of Medium:
Online Resource
ISSN:
1567-2050
DOI:
10.2174/1567205019666221007093500
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
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