In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-7), p. e0266523-
Abstract:
It has been speculated that shared mechanisms underlie respiratory and cardiovascular diseases (CVD) including systemic inflammation or mutual risk factors. In this context, we sought to examine the associations of CVD-related plasma proteins with lung function as measured by spirometry in a large community-based cohort of adults. Methods The study included 5777 Framingham Heart Study participants who had spirometry and measurement of 71 CVD-related plasma proteins. The association of plasma proteins with lung function was assessed cross-sectionally and longitudinally using models accounting for familial correlations. Linear mixed models were used for the following measurements: FEV 1%predicted , FVC %predicted , and FEV 1 /FVC ratio with secondary analyses examining obstructive and restrictive physiology at baseline and their new onset during follow up. Measurements and main results Among the 71 CVD-related plasma proteins, 13 proteins were associated in cross-sectional analyses with FEV 1%predicted , 17 proteins were associated with FVC %predicted , and 1 protein was associated with FEV 1 /FVC. The proteins with the greatest inverse relations to FEV 1%predicted and FVC %predicted included leptin, adrenomedullin, and plasminogen activator inhibitor-1; in contrast there were three proteins with positive relations to FEV 1%predicted and FVC %predicted including insulin growth factor binding protein 2, tetranectin, and soluble receptor for advanced glycation end products. In longitudinal analyses, three proteins were associated with longitudinal change in FEV 1 (ΔFEV 1 ) and four with ΔFVC; no proteins were associated with ΔFEV 1 /FVC. Conclusion Our findings highlight CVD-related plasma proteins that are associated with lung function including markers of inflammation, adiposity, and fibrosis, representing proteins that may contribute both to respiratory and CVD risk.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266523
DOI:
10.1371/journal.pone.0266523.g001
DOI:
10.1371/journal.pone.0266523.g002
DOI:
10.1371/journal.pone.0266523.g003
DOI:
10.1371/journal.pone.0266523.g004
DOI:
10.1371/journal.pone.0266523.t001
DOI:
10.1371/journal.pone.0266523.t002
DOI:
10.1371/journal.pone.0266523.t003
DOI:
10.1371/journal.pone.0266523.t004
DOI:
10.1371/journal.pone.0266523.t005
DOI:
10.1371/journal.pone.0266523.s001
DOI:
10.1371/journal.pone.0266523.s002
DOI:
10.1371/journal.pone.0266523.s003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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