In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2019-11-8), p. e1008493-
Kurzfassung:
Genomic GC content varies widely among microbes for reasons unknown. While mutation bias partially explains this variation, prokaryotes near-universally have a higher GC content than predicted solely by this bias. Debate surrounds the relative importance of the remaining explanations of selection versus biased gene conversion favoring GC alleles. Some environments (e.g. soils) are associated with a high genomic GC content of their inhabitants, which implies that either high GC content is a selective adaptation to particular habitats, or that certain habitats favor increased rates of gene conversion. Here, we report a novel association between the presence of the non-homologous end joining DNA double-strand break repair pathway and GC content; this observation suggests that DNA damage may be a fundamental driver of GC content, leading in part to the many environmental patterns observed to-date. We discuss potential mechanisms accounting for the observed association, and provide preliminary evidence that sites experiencing higher rates of double-strand breaks are under selection for increased GC content relative to the genomic background.
Materialart:
Online-Ressource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1008493
DOI:
10.1371/journal.pgen.1008493.g001
DOI:
10.1371/journal.pgen.1008493.g002
DOI:
10.1371/journal.pgen.1008493.g003
DOI:
10.1371/journal.pgen.1008493.g004
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10.1371/journal.pgen.1008493.g005
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10.1371/journal.pgen.1008493.t001
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10.1371/journal.pgen.1008493.s001
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10.1371/journal.pgen.1008493.s002
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10.1371/journal.pgen.1008493.s003
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10.1371/journal.pgen.1008493.s004
DOI:
10.1371/journal.pgen.1008493.s005
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10.1371/journal.pgen.1008493.s006
DOI:
10.1371/journal.pgen.1008493.s007
DOI:
10.1371/journal.pgen.1008493.s008
DOI:
10.1371/journal.pgen.1008493.s009
DOI:
10.1371/journal.pgen.1008493.s010
DOI:
10.1371/journal.pgen.1008493.s011
DOI:
10.1371/journal.pgen.1008493.s012
DOI:
10.1371/journal.pgen.1008493.s013
DOI:
10.1371/journal.pgen.1008493.s014
DOI:
10.1371/journal.pgen.1008493.r001
DOI:
10.1371/journal.pgen.1008493.r002
DOI:
10.1371/journal.pgen.1008493.r003
DOI:
10.1371/journal.pgen.1008493.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2019
ZDB Id:
2186725-2
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