In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 201, No. 5 ( 2012-11), p. 408-409
Abstract:
Despite accumulating evidence of structural deficits in individuals with
psychopathy, especially in frontal regions, our understanding of systems-level disturbances in cortical networks remains limited. We applied
novel graph theory-based methods to assess information flow and connectivity based on cortical thickness measures in 55 individuals with psychopathy and
47 normal controls. Compared with controls, the psychopathy group showed significantly altered interregional connectivity patterns. Furthermore,
bilateral superior frontal cortices in the frontal network were identified as information flow control hubs in the psychopathy group in contrast to
bilateral inferior frontal and medial orbitofrontal cortices as network hubs of the controls. Frontal information flow and connectivity may have a
significant role in the neuropathology of psychopathy.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.111.107128
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2012
detail.hit.zdb_id:
2021500-9
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