In:
Biomolecules and Biomedicine, Association of Basic Medical Sciences of FBIH, Vol. 14, No. 3 ( 2014-08-20), p. 177-184
Abstract:
The aim of the study was to investegate the correlation between the levels of CRP and YKL-40 in blood samples with morphometric parameters of retinal blood vessels in patients with diabetic retinopathy. Blood laboratory examination of 90 patients included the measurement of glycemia, HbA1C, total cholesterol, LDL-C, HDL-C, triglycerides and CRP. Levels of YKL-40 were detected and measured in serum by ELISA (Micro VueYKL-40 EIA Kit, Quidel Corporation, San Diego, USA). Morphmetric analysis was performed with ImageJ software (http://rsbweb.nih.gov/ij/) for digital retinal photography. We measured the number, diameter of retinal blood vessels in five different parts concentric to the optic disc. Differences between the morphometric parameters and the blood test analysis results were evaluated using the Student’s t – test. One Way ANOVA was used to establish the significance of differences. CRP and YKL-40 levels were moderately higher in the group of patients with severe diabetic retinopathy. Levels of YKL-40 correlated positively with diameter and negatively with number of retinal blood vessels. The average number of the blood vessels per retinal zone was significantly higher in the group of patients with mild non-proliferative diabetic retinopathy than in the group with severe form in the optic disc and all five retinal zones. The average outer diameter of the evaluated retinal zones and optic disc vessels was significantly higher in the group with severe compared to the group with mild diabetic retinopathy. Morphological analysis of the retinal vessels on digital fundus photography and correlation with YKL-40 may be valuable for the follow-up of diabetic retinopathy.
Type of Medium:
Online Resource
ISSN:
2831-090X
,
2831-0896
DOI:
10.17305/bjbms.2014.3.21
Language:
English
Publisher:
Association of Basic Medical Sciences of FBIH
Publication Date:
2014
detail.hit.zdb_id:
3149181-9
Bookmarklink