In:
Pathogens, MDPI AG, Vol. 10, No. 1 ( 2021-01-07), p. 48-
Abstract:
Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for TLR2 + 2477 G 〉 A, NOD1 + 32656 T − 〉 GG, CXCR5 + 10950 T 〉 C, and IL10 − 1082 A 〉 G. Results confirmed that NOD1 + 32656 T − 〉 GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1–3.4, p = 0.02), but we did not observe an association with late complications. IL10 − 1082 A 〉 G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1–7.1, p = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs’ role in the susceptibility and severity of a CT infection.
Type of Medium:
Online Resource
ISSN:
2076-0817
DOI:
10.3390/pathogens10010048
Language:
English
Publisher:
MDPI AG
Publication Date:
2021
detail.hit.zdb_id:
2695572-6
Bookmarklink