In:
Journal of Endocrinology, Bioscientifica, Vol. 88, No. 2 ( 1981-02), p. 289-292
Abstract:
The ability of 20α-hydroxy-4-pregnen-3-one (20α-dihydroprogesterone, 20α-DHP) and its 5α-reduced metabolites, 20α-hydroxy-5α-pregnan-3-one and 5α-pregnane-3α,20α-diol, to facilitate ovulation was examined in immature female rats which had been treated on day 22 of age with a non-ovulatory dose (12 i.u.) of pregnant mare serum gonadotrophin. An increased incidence of ovulation occurred in rats treated on the morning of day 24 with 20α-DHP. However, a dose of 20α-DHP three to four times that of progesterone was required to induce ovulation in all animals. In contrast, neither 20α-hydroxy-5α-pregnan-3-one (at doses ranging from 0·5 to 5·0 mg) nor 5α-pregnane-3α,20α-diol (tested at 3·0 or 4·0 mg) facilitated ovulation. Therefore both 20α-DHP and progesterone, the two major progestins of the rat oestrous cycle, have the ability to facilitate ovulation. It is concluded that the ability of 20α-DHP to facilitate ovulation does not appear to be by way of conversion to its 5α-reduced metabolites.
Type of Medium:
Online Resource
ISSN:
0022-0795
,
1479-6805
DOI:
10.1677/joe.0.0880289
Language:
Unknown
Publisher:
Bioscientifica
Publication Date:
1981
detail.hit.zdb_id:
1474892-7
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