In:
International Journal of Urology, Wiley, Vol. 12, No. 2 ( 2005-02), p. 199-203
Abstract:
Abstract Sarcomatoid transitional cell carcinoma is a rare entity, in which a malignant, overtly epithelial component coexists with areas having a sarcoma‐like appearance. Histological distinction of sarcomatoid carcinomas from carcinosarcomas is often difficult and immunohistochemistry is a helpful diagnostic adjunct in the correct diagnosis. In the present report, we describe an uncommon case of sarcomatoid transitional cell carcinoma of the renal pelvis, associated with giant cell tumor‐like features. Immunoperoxidase staining for cytokeratin was positive in spindle cell component, indicating an epithelial origin. The carcinomatous component showed a diffuse membranous reactivity for E‐cadherin, whereas the reactivity was sporadic and weaker in the sarcomatoid component, suggesting that the decrease of E‐cadherin expression might be associated with the acquisition of sarcomatous morphology. Osteoclast‐like multinucleated giant cells were positive for CD68 and negative for p53 oncoprotein, suggesting that they represent a non‐neoplastic component that is reactively induced in the tumor stroma.
Type of Medium:
Online Resource
ISSN:
0919-8172
,
1442-2042
DOI:
10.1111/iju.2005.12.issue-2
DOI:
10.1111/j.1442-2042.2005.01002.x
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2009793-1
Bookmarklink