In:
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, Vol. 82B, No. 2 ( 2007-08), p. 383-389
Abstract:
The fate of poly(vinyl alcohol) (PVA) of weight average molar mass of 125,000 g/mol after administration into the peritoneum of rabbits has bean studied by various methods. PVA was spin‐labeled with a nitroxide radical and then detected in urine using electron spin resonance (ESR) spectroscopy. Furthermore, unlabeled polymer was also administered to rabbits, then the urine was collected, dialyzed, precipitated, and the excretion of PVA was confirmed by size exclusion chromatography (SEC), FTIR spectroscopy, and 1 H NMR spectroscopy. ESR and SEC results show that, despite its relatively high molar mass, PVA is excreted through the kidneys without significant molar mass changes. Nevertheless, NMR and FTIR spectra show slight differences between the excreted and neat PVA. Possible causes of these discrepancies are discussed. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007
Type of Medium:
Online Resource
ISSN:
1552-4973
,
1552-4981
DOI:
10.1002/jbm.b.v82b:2
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2130917-6
SSG:
12
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