In:
Lupus, SAGE Publications, Vol. 25, No. 3 ( 2016-03), p. 282-288
Abstract:
In this study, we investigated the relationship between vitamin D, interferon-gamma (IFN-γ), and estradiol (E 2 ) in females of childbearing age with inactive systemic lupus erythematosus (SLE). The study included 22 SLE patients, and 21 age- and gender-matched healthy individuals. Serum concentrations of 25-hydroxyvitamin D 3 (25(OH)D 3 ), E 2 , and IFN-γ were measured by radioimmunoassay using the gamma-counter and ELISA. Patients and control subjects were divided into two groups based on their vitamin D levels (25(OH)D 3 ≤ 20 ng/mL; 25(OH)D 3 〉 20 ng/mL). The median values of IFN-γ and E 2 were higher in SLE patients compared to the controls, irrespective of vitamin D level ( p = 0.001, p = 0.009, p = 0.003, and p = 0.003, respectively). In SLE patients, there was a negative correlation between IFN-γ and 25(OH)D 3 ( r s = −0.330; p = 0.03) and a positive correlation between IFN-γ and E 2 ( r s = 0.404; p = 0.007). This study demonstrates an interesting interplay between vitamin D, INF-γ, and E 2 in SLE patients with inactive disease.
Type of Medium:
Online Resource
ISSN:
0961-2033
,
1477-0962
DOI:
10.1177/0961203315605367
Language:
English
Publisher:
SAGE Publications
Publication Date:
2016
detail.hit.zdb_id:
2008035-9
Bookmarklink