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Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways

Mikami, Daisuke ; Kobayashi, Mamiko ; Uwada, Junsuke ; [et al.]

Elsevier BV ; 2020

In: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Vol. 1865, No. 6 ( 2020-06), p. 158666-

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In: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Elsevier BV, Vol. 1865, No. 6 ( 2020-06), p. 158666-

Type of Medium: Online Resource

ISSN: 1388-1981

URL: Article

DOI: 10.1016/j.bbalip.2020.158666

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2209502-0

SSG: 12

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AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition

Mikami, Daisuke ; Kobayashi, Mamiko ; Uwada, Junsuke ; [et al.]

SAGE Publications ; 2020

In: Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592091343-

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In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592091343-

Abstract: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide and establishment of new chemotherapies for HCC is urgently needed. GPR41 [free fatty acid receptor 3 (FFA3)] is a G protein-coupled receptor for short chain fatty acids, including acetate, propionate, and butyrate. In our previous study, we showed that propionate enhances the cytotoxic effect of cisplatin in HCC cells and that this mechanism is dependent on inhibition of histone deacetylases (HDACs) via GPR41/FFA3. However, the antitumor action of GPR41/FFA3 has not been elucidated. Methods: In this study, we examined AR420626 as a GPR41-selective agonist in HepG2 and HLE cells. Nude mice were used for HepG2 xenograft studies. The apoptotic effect of AR420626 was evaluated using flow cytometry analysis. Expression of apoptosis-related proteins and HDACs was evaluated by Western immunoblot. Gene silencing of HDAC 3/5/7 and GPR41 was performed using small interfering RNA. Expression of TNF-α mRNA was evaluated by TaqMan real-time polymerase chain reaction. Results: We found that AR420626, a selective GPR41/FFA3 agonist, suppressed growth of HepG2 xenografts and inhibited proliferation of HCC cells by inducing apoptosis. AR420626 induced proteasome activation through mTOR phosphorylation, which reduced HDAC proteins, and then increased expression of TNF-α. Conclusion: AR420626, a selective GPR41/FFA3 agonist, may be a candidate as a therapeutic agent for HCC.

Type of Medium: Online Resource

ISSN: 1758-8359 , 1758-8359

URL: Article

DOI: 10.1177/1758835920913432

Language: English

Publisher: SAGE Publications

Publication Date: 2020

detail.hit.zdb_id: 2503443-1

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Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis

Kuroda, Hidekatsu ; Fujiwara, Yudai ; Abe, Tamami ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 4 ( 2021-4-7), p. e0249493-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-7), p. e0249493-

Abstract: We investigated the usefulness of combining two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter for assessing the risk of progressive non-alcoholic steatohepatitis, defined as non-alcoholic steatohepatitis with a non-alcoholic fatty liver disease activity score of ≥4 and a fibrosis stage of ≥2. Methods This prospective study included 202 patients with non-alcoholic fatty liver disease who underwent two-dimensional shear wave elastography, ultrasound-guided attenuation parameter, vibration-controlled transient elastography, the controlled attenuation parameter, and liver biopsy on the same day. Patients were grouped according to liver stiffness measurement using two-dimensional shear wave elastography and the attenuation coefficient, assessed using the ultrasound-guided attenuation parameter: A, low liver stiffness measurement/low attenuation coefficient; B, low liver stiffness measurement/high attenuation coefficient; C, high liver stiffness measurement/low attenuation coefficient; and D, high liver stiffness measurement/high attenuation coefficient. Results Two-dimensional shear wave elastography and vibration-controlled transient elastography had equivalent diagnostic performance for fibrosis. The areas under the curve of the ultrasound-guided attenuation parameter for identifying steatosis grades ≥S1, ≥S2, and S3 were 0.89, 0.91, and 0.92, respectively, which were significantly better than those of the controlled attenuation parameter (P 〈 0.05). The percentages of progressive non-alcoholic steatohepatitis in Groups A, B, C, and D were 0.0%, 7.7%, 35.7%, and 50.0%, respectively (P 〈 0.001). The prediction model was established as logit (p) = 0.5414 × liver stiffness measurement (kPa) + 7.791 × attenuation coefficient (dB/cm/MHz)—8.401, with area under the receiver operating characteristic curve, sensitivity, and specificity values of 0.832, 80.9%, and 74.6%, respectively; there was no significant difference from the FibroScan-aspartate aminotransferase score. Conclusion Combined assessment by two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter is useful for risk stratification of progressive non-alcoholic steatohepatitis and may be convenient for evaluating the necessity of specialist referral and liver biopsy.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0249493

DOI: 10.1371/journal.pone.0249493.g001

DOI: 10.1371/journal.pone.0249493.g002

DOI: 10.1371/journal.pone.0249493.g003

DOI: 10.1371/journal.pone.0249493.t001

DOI: 10.1371/journal.pone.0249493.t002

DOI: 10.1371/journal.pone.0249493.t003

DOI: 10.1371/journal.pone.0249493.t004

DOI: 10.1371/journal.pone.0249493.s001

DOI: 10.1371/journal.pone.0249493.s002

DOI: 10.1371/journal.pone.0249493.s003

DOI: 10.1371/journal.pone.0249493.s004

DOI: 10.1371/journal.pone.0249493.s005

DOI: 10.1371/journal.pone.0249493.s006

DOI: 10.1371/journal.pone.0249493.s007

DOI: 10.1371/journal.pone.0249493.r001

DOI: 10.1371/journal.pone.0249493.r002

DOI: 10.1371/journal.pone.0249493.r003

DOI: 10.1371/journal.pone.0249493.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

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β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells

Mikami, Daisuke ; Kobayashi, Mamiko ; Uwada, Junsuke ; [et al.]

Elsevier BV ; 2019

In: Life Sciences Vol. 222 ( 2019-04), p. 125-132

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In: Life Sciences, Elsevier BV, Vol. 222 ( 2019-04), p. 125-132

Type of Medium: Online Resource

ISSN: 0024-3205

URL: Article

DOI: 10.1016/j.lfs.2019.03.008

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2013911-1

SSG: 12

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Wake behind circular cylinder excited by spanwise non-uniform disturbances

Kamiyama, Takumi ; Ino, Mizuki ; Yokota, Yudai ; [et al.]

Paul V. Galvin Library/Illinois Institute of Technology ; 2021

In: 14th International Symposium on Particle Image Velocimetry Vol. 1, No. 1 ( 2021-08-01)

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In: 14th International Symposium on Particle Image Velocimetry, Paul V. Galvin Library/Illinois Institute of Technology, Vol. 1, No. 1 ( 2021-08-01)

Abstract: We studied a modification of wake behind a circular cylinder using a plasma actuator. The plasma actuators were arranged in the spanwise direction of the cylinder to give temporal periodic disturbances having Strouhal number St = 0.18-2.3 with a burst ratio BR = 20 and 40%. The Reynolds number was set in a rage of Re = 4200 to 8400. Two types of plasma actuator were prepared; one is a single strip of the actuator placed at each side of the cylinder to give a spanwise uniform disturbance, and another is an array of small piece of actuators placed at the same location to create a spanwise non-uniform disturbance with temporal phase difference, φ = 0 or π, between adjacent electrodes. A conventional two-component PIV and stereo PIV was used to measure the flow field. Figure 1 shows the instantaneous spanwise component of vorticity at Re = 4200 evaluated by two-component PIV. Under no disturbance condition, the laminar shear layer extends straight to around x / d = 1.5 and then forms a wake vortex, as shown in Fig.1(a). In the case of spanwise non-uniform forcing with St = 1.09 and φ =π, rapid roll up of the initial shear layer leads to arrangement of wake vortices closer to the cylinder., as shown in Fig.1(b). With higher Strouhal number case with St = 1.09 and φ = 0, shown in Fig.1(c), a series of fine scale vortices are generated behind both side of the cylinder without forming regular Karman vortices. The spanwise non-uniform forcing was effective to suppress the formation of large scale vortices just behind the cylinder. Figure 2 shows surface of constant vorticity magnitude and vortex lines under St =1.09 and φ = π case. These were computed from a phase-averaged threecomponents velocity field evaluated by stereo PIV. The value of the surface was selected to display the boundary layer formed on the cylinder, and the vortex lines are selected to visualize the vortex structure formed in the following shear layer. A bundle of vortex lines are shaped in a wavy pattern along spanwise direction with 180 degrees out of phase to the adjacent bundle upstream of downstream. This structure, so called ‘chain-line fence structure’ was already found in planar free shear layer [Nygaard, K.J. and Glezer, A., 1990, Phys. Fluids A, 2, 461] and planar jet [Sakakibara, J., Anzai, T., 2001, Phys. Fluids, 13, 1541], but it became evident to create it in the wake of circular cylinder in this study.

Type of Medium: Online Resource

ISSN: 2769-7576

URL: Issue

URL: Article

DOI: 10.18409/ispiv.v1i1

DOI: 10.18409/ispiv.v1i1.42

Language: Unknown

Publisher: Paul V. Galvin Library/Illinois Institute of Technology

Publication Date: 2021

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Recovery of phosphorus, magnesium, and potassium from surplus activated sludge using existing sludge treatment facilities and thickened primary sludge

Kamiyama, Yudai ; Shiraiwa, Takuya ; Ishikawa, Nao ; [et al.]

IWA Publishing ; 2024

In: Water Science & Technology Vol. 89, No. 3 ( 2024-02-01), p. 670-681

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In: Water Science & Technology, IWA Publishing, Vol. 89, No. 3 ( 2024-02-01), p. 670-681

Abstract: The separation of P, K, and Mg from surplus activated sludge (SAS) was investigated using existing sludge treatment facilities and the thickened primary sludge (TPS). The addition of the TPS to the SAS storage tank accelerated the anaerobic release of the three elements from SAS with maximum efficiencies of about 60%. The efficiency of P release showed a significant correlation with the oxidation–reduction potential. Increasing the total solid concentration increased the release of elements. The released elements could be transferred to a separate liquid (SL) from a screw-press thickener, and maximum concentrations of P, K, and Mg were about 200, 60, and 35 mg/L, respectively. The addition of CaCl2 and NaOH solutions to SL precipitated P as hydroxyapatite. However, no precipitation of K and Mg occurred simultaneously with P, even when the pH of SL was increased to 9. These findings suggest that about 60% of P, K, and Mg can be separated from SAS into SL using existing sludge treatment facilities and TPS; however, a method other than precipitation would be needed to recover P and K from SL simultaneously.

Type of Medium: Online Resource

ISSN: 0273-1223 , 1996-9732

URL: Article

DOI: 10.2166/wst.2024.013

Language: English

Publisher: IWA Publishing

Publication Date: 2024

detail.hit.zdb_id: 764273-8

detail.hit.zdb_id: 2024780-1

SSG: 14

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Accuracy of 2D shear wave elastography in the diagnosis of liver fibrosis in patients with chronic hepatitis C

Abe, Tamami ; Kuroda, Hidekatsu ; Fujiwara, Yudai ; [et al.]

Wiley ; 2018

In: Journal of Clinical Ultrasound Vol. 46, No. 5 ( 2018-06), p. 319-327

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In: Journal of Clinical Ultrasound, Wiley, Vol. 46, No. 5 ( 2018-06), p. 319-327

Abstract: This prospective study was conducted to assess the diagnostic accuracy of two‐dimensional shear wave elastography (2D SWE) in the diagnosis of liver fibrosis in patients with chronic liver disease and hepatitis C virus (HCV) compared with the serum liver fibrosis biomarkers using the results of liver biopsy as the reference standard. Methods We analyzed 233 consecutive HCV patients. On the same day, 2D SWE m, biochemical tests, and liver biopsy were performed. We used the METAVIR staging system and receiver operating characteristic curves for the analysis. Results The success rate of 2D‐SWE was 98.7%. The median shear wave velocities (SWVs) of patients in the F0, F1, F2, F3, and F4 stages were 1.35 m/s, 1.42 m/s, 1.58 m/s, 1.83 m/s, and 2.13 m/s, respectively, demonstrating a stepwise increase ( P 〈 .0001). The accuracy of 2D‐SWE in the prediction of ≥F1, ≥F2, ≥F3, and F4 was .888 (95% CI: .85‐.93), .915 (95% CI: .88‐095), .940 (95% CI: .91‐.97), and .949 (95% CI: .92‐.97), respectively. 2D‐SWE was significantly superior to serum liver fibrosis biomarkers. Conclusion 2D‐SWE was positively correlated with the severity of liver fibrosis and was more useful for to predict all liver fibrosis grades in HCV patients than liver fibrosis biomarkers.

Type of Medium: Online Resource

ISSN: 0091-2751 , 1097-0096

URL: Issue

URL: Article

DOI: 10.1002/jcu.v46.5

DOI: 10.1002/jcu.22592

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 1492376-2

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Multivariable Quantitative US Parameters for Assessing Hepatic Steatosis

Kuroda, Hidekatsu ; Oguri, Takuma ; Kamiyama, Naohisa ; [et al.]

Radiological Society of North America (RSNA) ; 2023

In: Radiology Vol. 309, No. 1 ( 2023-10-01)

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In: Radiology, Radiological Society of North America (RSNA), Vol. 309, No. 1 ( 2023-10-01)

Type of Medium: Online Resource

ISSN: 0033-8419 , 1527-1315

URL: Article

DOI: 10.1148/radiol.230341

RVK:

XA 10000

Language: English

Publisher: Radiological Society of North America (RSNA)

Publication Date: 2023

detail.hit.zdb_id: 80324-8

detail.hit.zdb_id: 2010588-5

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Measurement of Ultrasound Attenuation for Quantifying Amount ff Fat in Chronic Liver Disease

Oguri, Takuma ; Kamiyama, Naohisa ; Kuroda, Hidekatsu ; [et al.]

Elsevier BV ; 2017

In: Ultrasound in Medicine & Biology Vol. 43 ( 2017), p. S157-S158

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In: Ultrasound in Medicine & Biology, Elsevier BV, Vol. 43 ( 2017), p. S157-S158

Type of Medium: Online Resource

ISSN: 0301-5629

URL: Article

DOI: 10.1016/j.ultrasmedbio.2017.08.1520

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 1498918-9

SSG: 12

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Treatment of permanent tracheostomal stenosis with local steroid injection

Shinkai, Toko ; Masumoto, Kouji ; Kamiyama, Miki ; [et al.]

Elsevier BV ; 2023

In: Journal of Pediatric Surgery Case Reports Vol. 91 ( 2023-04), p. 102573-

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In: Journal of Pediatric Surgery Case Reports, Elsevier BV, Vol. 91 ( 2023-04), p. 102573-

Type of Medium: Online Resource

ISSN: 2213-5766

URL: Article

DOI: 10.1016/j.epsc.2022.102573

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2715451-8

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