In:
The Journal of Immunology, The American Association of Immunologists, Vol. 179, No. 4 ( 2007-08-15), p. 2163-2169
Abstract:
Interactions between TCR and self-peptide/MHC complex play an important role in homeostasis and Ag reactivity of mature peripheral T cells. In this report, we demonstrate that the interactions between mature peripheral T cells and endogenous Ags have a negative impact on the maintenance of foreign Ag-specific T cells in an age-dependent manner. This is mediated by RAG-dependent secondary rearrangement of the TCR α-chain (receptor revision). The TCR revision in mature T cells is readily observed in mouse expressing transgenic TCR α-chain inserted into the physiological locus (knockin mouse) but not in conventional transgenic mouse with an identical TCR α-chain. Thus, our results suggest that under physiological conditions in which all TCR α-chains are susceptible to deletion by secondary rearrangement, TCR revision in mature peripheral T cells is an ongoing process in adult animals and contributes to age-dependent changes in T cell function and repertoire.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.179.4.2163
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2007
detail.hit.zdb_id:
1475085-5
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