In:
Nuclear Medicine Communications, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 8 ( 2020-8), p. 733-739
Abstract:
The aim of this study was to evaluate a prognostic value of the extent of metastatic lymph node combined with TSH-stimulated serum thyroglobulin (sTg) measured just before radioactive iodine (RAI) therapy in patients with papillary thyroid cancer (PTC). Methods The retrospective study included 468 patients with PTC who underwent total thyroidectomy with neck dissection and postoperative RAI therapy. The extent of metastatic lymph node was evaluated with the lymph node ratio (LNR) which was defined as the number of metastatic lymph nodes out of the number of total removed lymph nodes. We investigated which factors could significantly predict persistent or recurrent disease (PRD). Results LNR ≥0.4 ( P = 0.002) and sTg ≥6.0 ng/mL ( P 〈 0.001) were associated with PRD in univariate analysis. In multivariate analysis, only male [hazard ratio: 2.35, 95% confidence interval (CI): 1.18–4.66, P = 0.014] and sTg (hazard ratio: 9.35, 95% CI: 4.44–19.67, P 〈 0.001) were associated with PRD prediction. When we divided patients into two groups (patients with sTg level 〈 6.0 ng/mL and those with sTg level ≥ 6.0 ng/mL), LNR (≥0.4) was a significant predictor of PRD in patients with sTg 〈 6.0 ng/mL (hazard ratio: 4.38, 95% CI: 1.22–15.72, P = 0.024). Conclusions LNR ≥0.4 was a significant predictor of PRD when the sTg level was 〈 6.0 ng/mL. LNR should be used in combination with a relatively low level of serum sTg to predict the prognosis of patients with PTC.
Type of Medium:
Online Resource
ISSN:
0143-3636
DOI:
10.1097/MNM.0000000000001214
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2020
detail.hit.zdb_id:
2028880-3
Bookmarklink