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  • 1
    Online Resource
    Online Resource
    Partial purification and characterization of protease extracted from kinema
    Elsevier BV ; 2024
    In:  Heliyon Vol. 10, No. 5 ( 2024-03), p. e27173-
    Details
    In: Heliyon, Elsevier BV, Vol. 10, No. 5 ( 2024-03), p. e27173-
    Type of Medium: Online Resource
    ISSN: 2405-8440
    URL: Article
    DOI: 10.1016/j.heliyon.2024.e27173
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2835763-2
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  • 2
    Online Resource
    Online Resource
    Gender Difference in the Coronary Risk Factors Amongst the Patients with Acute Coronary Events in Nepal
    Nepal Journals Online (JOL) ; 2019
    In:  Nepalese Heart Journal Vol. 2, No. 2 ( 2019-12-18), p. 7-12
    Details
    In: Nepalese Heart Journal, Nepal Journals Online (JOL), Vol. 2, No. 2 ( 2019-12-18), p. 7-12
    Abstract: Background: Acute Coronary Event (ACE) is the commonest cause of admission in Coronary Care Unit (CCU) in Nepal. With growing epidemic of coronary artery disease in Asian countries, there is an urgent need to assess the locally prevalent coronary risk factors. There seems to be a significant difference in the risk factors amongst male and female population. Methods: A prospective analysis was done in 404 consecutive patients admitted with an acute coronary event in CCU in the Norvic Escorts Health Care And Research Centre, Kathmandu from January 1999 to July 2002. The data was analyzed and various risk factors were stratified. Results: Out of 404 patients of ACE, 251 (62%) patients were males and 153 (38%) patients were females. The commonest risk factors amongst male patients were smoking in 160 (64%), hypertension in 148 (59%) and dyslipidemia in 133(53%), followed by diabetes in 80 (32%) and a positive family history in 65 (26%) patients. As against this, female patients had commonest risk factors as hypertension in 71 (47%), diabetes in 71 (47%) and smoking in 64 (42%), followed by a positive family history in 47 (31%), and dyslipidemia in 23 (15%) patients. Conclusions: Smoking is the most common risk factor followed by Hypertension and Dyslipidemia in male patients with ACE, but most female patients with ACE have Hypertension as the most common coronary risk factor followed by diabetes mellitus. This may be partly due to the difference of socio-economic status of two genders in Nepal. An aggressive preventive approach is mandatory to decrease the expensive burden of coronary artery disease in this poor Himalayan country.
    Type of Medium: Online Resource
    ISSN: 2382-5464 , 2091-2978
    URL: Article
    DOI: 10.3126/njh.v2i2.26032
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2019
    detail.hit.zdb_id: 2901174-7
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  • 3
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    Online Resource
    Coronary Calcium Scoring and Modifiable Coronary Risk Factors
    Lumbini Medical College ; 2017
    In:  Journal of Lumbini Medical College Vol. 5, No. 2 ( 2017-12-14), p. 54-57
    Details
    In: Journal of Lumbini Medical College, Lumbini Medical College, Vol. 5, No. 2 ( 2017-12-14), p. 54-57
    Abstract: Introduction: Non-invasive coronary calcium scoring predicts earliest atherosclerotic changes in the coronary arteries on the basis of amount of calcium deposited in the coronary arteries. This study was done to analyze calcium scores in-patient with different risk factors for coronary artery disease (CAD). Methods: This was a cross sectional study conducted from 1st November 2015 to 30th April 2016 at Kathmandu Medical College Teaching Hospital. Patient with cardiovascular risk factors were included in the study. These patients underwent coronary calcium scoring. Calcium scores were then compared with the presence of risk factors. Results: Total 467 participants were included in the study. There were 309 (62.2%) males and 158 (33.8%) females. Mean age of patient was 56.6 year (SD = 12.7). The difference in the scores observed with presence or absence of risk factors were statistically significant for gender, smoking, and hypertriglyceridemia (p 〈 0.05) but not significant for impaired fasting glucose, hypertension, and body mass index. Conclusion: This study suggested that presence of traditional risk factors does not necessarily indicate high coronary calcium level.
    Type of Medium: Online Resource
    ISSN: 2542-2618 , 2392-4632
    URL: Article
    DOI: 10.22502/jlmc.v5i2.144
    Language: Unknown
    Publisher: Lumbini Medical College
    Publication Date: 2017
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  • 4
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    Online Resource
    Vitamin D Deficiency among Patients Visiting a Tertiary Care Hospital: A Descriptive Cross-sectional Study
    Journal of Nepal Medical Association (JNMA) ; 2020
    In:  Journal of Nepal Medical Association Vol. 58, No. 231 ( 2020-11-22)
    Details
    In: Journal of Nepal Medical Association, Journal of Nepal Medical Association (JNMA), Vol. 58, No. 231 ( 2020-11-22)
    Abstract: Introduction: Vitamin D deficiency is a common condition prevalent among both developed and developing countries where it is seen mostly in females. It has been linked to various skeletal and non-skeletal diseases. This study was done to find out the prevalence of Vitamin D deficiency and clinical features of deficient patients attending the outpatient department of a tertiary care hospital. Methods: This descriptive cross-sectional study was done among the patients attending the outpatient department of a tertiary care hospital in Kathmandu, Nepal. The study was conducted from May 2019 to July 2019. The ethical approval was taken from the Institutional Review Committee (ref no. 310520113). Convenient sampling was done. The collected data was entered in Microsoft Excel and was analyzed in the Statistical Package for the Social Sciences (SPSS) version 26. Results: Out of 481 participants, the prevalence of vitamin D deficiency was 335 (69.6%). Severe vitamin D deficiency was seen in 78 (16.2%) and insufficient vitamin D in 77 (16%) of the patients. The mean serum vitamin D concentration by gender was 22.38±17.07 ng/ml in males and 18.89±15.25 ng/ml in females. A total of 263 (54.6%) females and 72 (14.97%) males had vitamin D deficiency. The most common symptoms found in vitamin D deficiency patients were fatigue 187(55.8%), muscle cramps 131(39.1%), generalized myalgia 125(37.31%), bone and joint pain 111(33.13%) Conclusions: Vitamin D deficiency was prevalent especially in females and elderly people. Fatigability was present in more than half of the vitamin D deficient patients.
    Type of Medium: Online Resource
    ISSN: 1815-672X , 0028-2715
    URL: Article
    DOI: 10.31729/jnma.5645
    Language: Unknown
    Publisher: Journal of Nepal Medical Association (JNMA)
    Publication Date: 2020
    detail.hit.zdb_id: 2209910-4
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  • 5
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    Online Resource
    Right Ventricular Dimensions and Tricuspid Annular Plane Systolic Excursion among Medical Students of Tertiary Care Hospital: A Descriptive Cross-sectional Study
    Journal of Nepal Medical Association (JNMA) ; 2020
    In:  Journal of Nepal Medical Association Vol. 58, No. 229 ( 2020-09-27)
    Details
    In: Journal of Nepal Medical Association, Journal of Nepal Medical Association (JNMA), Vol. 58, No. 229 ( 2020-09-27)
    Abstract: Introduction: The change in morphology and functions of the right ventricle is an important predictor of heart and lung disease. There is limited data on the normal dimension of the right ventricle. The study aimed to find the right ventricular diameter, its thickness, and tricuspid annular plane systolic excursion in healthy male medical students of a tertiary care hospital. Methods: It is a descriptive cross-sectional study conducted in healthy medical students of Kathmandu Medical College and Teaching Hospital, from February-April, 2019. Ethical approval was taken from the institutional review committee (reference number 120720193). Convenient sampling method was used. We measured various dimensions of the right ventricle in different views. The data was analyzed in the Statistical Package for the Social Sciences. Results: In the 96 male students included in the study, the mean right ventricular basal diameter was 36.45±3.49 mm, right ventricular mid cavity diameter was 29±3.63 mm, right ventricular longitudinal dimension was 65.72±7.52 mm, right ventricular outflow tract in parasternal long-axis view was 27.07±2.12 mm, proximal and distal right ventricular outflow in parasternal short-axis view was 25.33±2.57 mm and 20.08±1.99 mm, right ventricular thickness was 4.20±0.54 mm, and tricuspid annular plane systolic excursion was 23.02±3.54 mm. Conclusions: The study found that the values of right ventricular dimensions and the right ventricle's tricuspid annular plane systolic excursion among male medical students of a tertiary care hospital to be in accordance with the guidelines by the American Society of Echocardiography. The upper limits of the normal values of the right ventricle could be very helpful in clinical practice in determining the right ventricle dimension.
    Type of Medium: Online Resource
    ISSN: 1815-672X , 0028-2715
    URL: Article
    DOI: 10.31729/jnma.5302
    Language: Unknown
    Publisher: Journal of Nepal Medical Association (JNMA)
    Publication Date: 2020
    detail.hit.zdb_id: 2209910-4
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  • 6
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    Prevalence of Atrial Fibrillation in Obstructive Sleep Apnea Patients in a Tertiary Care Center
    Journal of Nepal Medical Association (JNMA) ; 2020
    In:  Journal of Nepal Medical Association Vol. 58, No. 222 ( 2020-02-29)
    Details
    In: Journal of Nepal Medical Association, Journal of Nepal Medical Association (JNMA), Vol. 58, No. 222 ( 2020-02-29)
    Abstract: Introduction: Atrial fibrillation is the most common sustained arrhythmias.Recently there has been evidence of higher prevalence of atrial fibrillation in obstructive sleep apnea patients compared to the general population. The aim of this study was to find the prevalence of atrial fibrillation in patients of obstructive sleep apnea in a tertiary care center. Methods: This descriptive cross-sectional study was done in Om Hospital and Research Centre from January 2016 to 2018 March after ethical clearance. Convenience sampling was done. Data was collected and entry was done in microsoft excel, point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: The prevalence of atrial fibrillation in patients with obstructive sleep apnea is 7 (10.44%) at 95% Confidence Interval (6.70-14.17%). Apnoea–Hypopnoea Index of more than 30was present in 3 (42.8%) patients of atrial fibrillation. Atrial fibrillation was seen highest, 3 (42.8%) in patients with BMI more than 30 and lowest, 1 (14.28%) patients with BMI less than 23.5. Prevalence of atrial fibrillation was seen 5 (71.4%) in male patients and 2 (28.57%) in female patients. Sixty seven (75.28%) patients had obstructive sleep apnea in which male patients was predominant 48 (71.64%). Conclusions: Prevalence ofatrial fibrillation in patients of obstructive sleep apnea was found to higher than the similar studies done. It is important to obtain detail cardiac history in any patients with obstructive sleep apnea and look for arrhythmias speciallyatrial fibrillation.
    Type of Medium: Online Resource
    ISSN: 1815-672X , 0028-2715
    URL: Article
    DOI: 10.31729/jnma.4812
    Language: Unknown
    Publisher: Journal of Nepal Medical Association (JNMA)
    Publication Date: 2020
    detail.hit.zdb_id: 2209910-4
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