In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 6 ( 2021-6-4), p. e0252401-
Abstract:
The purpose of the current study was to clarify differences in microRNA expression according to clinicopathological characteristics, and to investigate if miRNA profiles could predict cytoreductive outcome in patients with FIGO stage IIIC and IV ovarian cancer. Patients enrolled in the Pelvic Mass study between 2004 and 2010, diagnosed and surgically treated for epithelial ovarian cancer, were used for investigation. MicroRNA was profiled from tumour tissue with global microRNA microarray analysis. Differences in miRNA expression profiles were analysed according to histologic subtype, FIGO stage, tumour grade, type I or II tumours and result of primary cytoreductive surgery. One microRNA, miR-130a, which was found to be associated with serous histology and advanced FIGO stage, was also validated using data from external cohorts. Another seven microRNAs (miR-34a, miR-455-3p, miR-595, miR-1301, miR-146-5p, 193a-5p, miR-939) were found to be significantly associated with the clinicopathological characteristics ( p ≤ 0.001), in our data, but mere not similarly significant when tested against external cohorts. Further validation in comparable cohorts, with microRNA profiled using newest and similar methods are warranted.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0252401
DOI:
10.1371/journal.pone.0252401.g001
DOI:
10.1371/journal.pone.0252401.t001
DOI:
10.1371/journal.pone.0252401.t002
DOI:
10.1371/journal.pone.0252401.t003
DOI:
10.1371/journal.pone.0252401.t004
DOI:
10.1371/journal.pone.0252401.t005
DOI:
10.1371/journal.pone.0252401.s001
DOI:
10.1371/journal.pone.0252401.s002
DOI:
10.1371/journal.pone.0252401.s003
DOI:
10.1371/journal.pone.0252401.s004
DOI:
10.1371/journal.pone.0252401.s005
DOI:
10.1371/journal.pone.0252401.s006
DOI:
10.1371/journal.pone.0252401.r001
DOI:
10.1371/journal.pone.0252401.r002
DOI:
10.1371/journal.pone.0252401.r003
DOI:
10.1371/journal.pone.0252401.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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